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Successful treatment of JMML relapsed after unrelated allogeneic transplant with cytoreduction followed by DLI and interferon-alpha: evidence for a graft-versus-leukemia effect in non-monosomy-7 JMML

Bone Marrow Transplantation volume 33, pages 113–115 (2004)Cite this article

Summary:

Relapse is the major cause of treatment failure after allogeneic transplantation of children with juvenile myelomonocytic leukemia (JMML), and the role of post-transplant immunomodulation is poorly understood. We report a 12-month-old child with JMML relapsed after unrelated marrow transplantation who received cytoreduction followed by donor lymphocyte infusion (DLI) with improvement, and after addition of interferon-alpha (IFN) achieved complete donor chimerism. He was weaned from IFN and has maintained complete remission for 19 months. This is the first published report of a patient with non-monosomy-7 JMML responding to post-transplant immunomodulation and suggests a role for DLI plus IFN in these patients.

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Authors and Affiliations

  1. Blood and Marrow Transplant Program, Salt Lake City, UT, USA

    M A Pulsipher, J Asch & F B Petersen

  2. Blood and Marrow Transplant Program, Mayo Clinic, Scottsdale, AZ, USA

    R H Adams

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  1. M A Pulsipher
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  2. R H Adams
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  3. J Asch
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  4. F B Petersen
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Correspondence to M A Pulsipher.

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Pulsipher, M., Adams, R., Asch, J. et al. Successful treatment of JMML relapsed after unrelated allogeneic transplant with cytoreduction followed by DLI and interferon-alpha: evidence for a graft-versus-leukemia effect in non-monosomy-7 JMML. Bone Marrow Transplant 33, 113–115 (2004). https://doi.org/10.1038/sj.bmt.1704287

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