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Should HIV-positive patients with lymphoma be offered stem cell transplants?

Bone Marrow Transplantation volume 32, pages 741–748 (2003)Cite this article

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Advances in effective antiretroviral therapy for HIV infection have made high-dose therapy and autologous stem cell transplantation possible in patients with HIV-associated lymphomas. Regimen-related toxicity is not significantly increased when antiretroviral therapy is combined with high-dose chemoradiotherapy. Durable engraftment can be seen with autologous stem cell rescue. Infectious complications can be managed with a combination of surveillance and prophylaxis. Long-term remissions of these high-risk lymphomas can be achieved with this approach. This suggests that patients with HIV-associated lymphomas should be considered for autologous transplantation in a manner similar to HIV-negative lymphoma patients

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Acknowledgements

We thank Dr David Smith and Jason Chapman, CRA for statistical support, Diana Garcia for manuscript preparation, Debra Vasquez, RN for transplant coordination and the clinical staff in the Division of Hematology and Bone Marrow Transplantation at the City of Hope.

This work was supported in part by United States Public Health Science Grants CA 30206, CA 33572, A138592, and Grant MO1-RR-43 from the General Clinical Research Center branch of the National Center for Research Resources, National Institutes of Health. AK is the recipient of a Lymphoma Research Foundation of America award.

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  1. Hematologic Neoplasia Program, City of Hope Comprehensive Cancer Center, Duarte, CA, USA

    A Krishnan, J Zaia & S J Forman

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  1. A Krishnan
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  2. J Zaia
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  3. S J Forman
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Correspondence to A Krishnan.

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Krishnan, A., Zaia, J. & Forman, S. Should HIV-positive patients with lymphoma be offered stem cell transplants?. Bone Marrow Transplant 32, 741–748 (2003). https://doi.org/10.1038/sj.bmt.1704270

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