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Utility of antigenemia test for cytomegalovirus detection in hematopoietic transplant recipients: report of experiences from Medellín, Colombia

Bone Marrow Transplantation volume 32, pages 119–120 (2003)Cite this article

Very few reports have been published in Latin America about cytomegalovirus infection and disease in bone marrow transplant (BMT) patients. In spite of the economic, political and social difficulties, such patients deserve an appropriate and opportune treatment for their illness. With limited resources, it has been possible to establish programs of hematopoietic transplants that have given good results.1 Even so, the prevalence of infection for cytomegalovirus (CMV) in those patients is a problem, since prompt diagnosis is necessary to minimize morbidity and mortality. The antigenemia pp65 assay for CMV is a quick and economic test to detect the reactive infection for CMV.2 This report describes our experience with the antigenemia test for the diagnosis of CMV infection in our BMT unit at the Hospital Universitario San Vicente de Paul, University of Antioquia, Medellín, Colombia.

Between January 2000 and December 2001, 211 peripheral blood samples were processed for detection of CMV antigen pp65 using the antigenemia test (CMV Brite, IQ corporation, Groningen, The Netherlands). These samples were obtained from 19 allo-transplanted patients (17 PBSC, one bone marrow and one unrelated UCB). We reviewed demographic data, clinical evolution and treatment for each patient from clinical records. All donors and recipients had pretransplant CMV positive serology (Table 1). The management protocol for hematopoietic transplant recipients in our hospital includes a weekly antigenemia test during the first 100 days post-transplant and at any time thereafter the physician considered necessary.

Table 1 Clinical characteristics of patients
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Acknowledgements

We thank Gene M Shearer and Maria T Rugeles for their helpful comments and manuscript review.

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Authors and Affiliations

  1. Immunovirology Group, BIOGENESIS School of Medicine, University of Antioquia, Medellín, Colombia

    M Sarmiento-Maldonado & M Eugenia Castaño-Orozco

  2. Director of Cytomegalovirus Research Division Immunovirology Group BIOGENESIS, School of Medicine, University of Antioquia, Medellín, Colombia

    V I Bedoya-Escobar

  3. Blood and Marrow Transplantation Unit School of Medicine University of Antioquia Hospital Universitario San Vicente of Paúl, Carrera 51D # 62-29, Medellín, Colombia

    S Calle-Fernandez, M Velásquez-Lopera, R Gomez-Wolff, A Karduss Urueta & F Cuellar-Ambrosi

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  1. M Sarmiento-Maldonado
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  2. M Eugenia Castaño-Orozco
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  8. F Cuellar-Ambrosi
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Sarmiento-Maldonado, M., Eugenia Castaño-Orozco, M., Bedoya-Escobar, V. et al. Utility of antigenemia test for cytomegalovirus detection in hematopoietic transplant recipients: report of experiences from Medellín, Colombia. Bone Marrow Transplant 32, 119–120 (2003). https://doi.org/10.1038/sj.bmt.1704063

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