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Autologous Hematopoietic Stem Cell Transplantation for Autoimmune Diseases

Long-term follow-up of autologous stem cell transplantation for refractory juvenile idiopathic arthritis

Bone Marrow Transplantation volume 32, pages S61–S64 (2003)Cite this article

Summary:

Since 1997, autologous stem cell transplantation (ASCT) had been applied to more than 40 children with polyarticular or systemic juvenile idiopathic arthritis (JIA). For this review, results of the follow-up are available from 25 children with systemic JIA and six with polyarticular JIA that were reported in detail from eight different pediatric European transplant centers. Before ASCT all children had progressive disease despite the use of corticosteroids, methotrexate (MTX) up to 1 mg/kg/week, cyclosporin (2.5 mg/kg/day) and/or anti-TNFα therapy. The clinical follow-up of these children ranges from 8 to 60 months (median 33 months).

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Acknowledgements

Patient data were obtained from nine pediatric university centers in Europe. The clinical studies in the Netherlands were supported in part by a grant from the Dutch League against Rheumatism. LW was supported by a grant from SPARKS (Sport Aiding Medical Research for Kids).

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Authors and Affiliations

  1. Department of Pediatrics, University Medical Center Utrecht, The Netherlands

    N M Wulffraat, I de Kleer & W Kuis

  2. Department of Pediatrics, Leiden University Medical Center, Leiden, The Netherlands

    D Brinkman & R ten Cate

  3. Department of Rheumatology, Université Erasme, Bruxelles, Belgium

    A Ferster

  4. Carl Thiem Klinikum, Cottbus, Germany

    J Opperman

  5. Rheumatology Unit, Institute of Child Health and Great Ormond Street Children's Hospital, University College London, England

    L Wedderburn

  6. Department of Rheumatology, Newcastle General Hospital, Newcastle upon Tyne, England

    H Foster

  7. Department of Pediatric Immunology, Newcastle General Hospital, Newcastle Upon Tyne, England

    M Abinun

  8. Unite d'Immuno-Hematologie et Rheumatologie Pediatriques, Hopital Necker-Enfants Malades, Paris, France

    A M Prieur

  9. Department of Pediatrics, University Hospital Halle, Germany

    G Horneff

  10. Department of Pediatrics, University of Jena, Germany

    F Zintl

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  1. N M Wulffraat
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  2. D Brinkman
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  5. R ten Cate
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  9. A M Prieur
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  13. W Kuis
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Wulffraat, N., Brinkman, D., Ferster, A. et al. Long-term follow-up of autologous stem cell transplantation for refractory juvenile idiopathic arthritis. Bone Marrow Transplant 32 (Suppl 1), S61–S64 (2003). https://doi.org/10.1038/sj.bmt.1703946

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