Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Graft-Versus-Host Disease

Recipient mHag-HA1 disparity and aGVHD in thalassemic-transplanted patients

Bone Marrow Transplantation volume 31, pages 575–578 (2003)Cite this article

Summary:

In order to determine the influence of HA-1 minor histocompatibility antigen mismatch on BMT outcome, we analyzed a pool of 94 thalassemic transplanted patients all selected for the presence of HLA-A*0201 allele. The HA-1 typing was performed using SSP analysis. All the patients received bone marrow from HLA-identical MLC nonresponsive siblings. As graft-versus-host-disease (GVHD) prophylaxis, all patients received cyclosporin and short methotrexate. Grades II–IV GVHD occurred in five (33.3%) of the 15 patients with recipient HA-1 disparity compared with 14 (17.7%) of the 79 patients without HA-1 disparity. Despite the higher incidence of acute graft-versus-host-disease (aGVHD) in the group of patients with HA-1 incompatibility, these data were not statistically significant. However, it was interesting to observe that no GVHD developed in any of the 15 cases in which the recipient was HA-1 negative and the donor HA-1 positive.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Sullivan KM . Graft-versus-host disease. In: Forman SJ, Blume KG, Thomas DE (eds). Bone Marrow Transplantation. Blackwell: Boston, 1994, pp 339–362.

    Google Scholar 

  2. Lucarelli G, Galimberti M, Polchi P et al. Marrow transplantation in patients with thalassemia responsive to iron chelation therapy. N Engl J Med 1993; 329: 840–844.

    Article  CAS  Google Scholar 

  3. Gaziev D, Polchi P, Galimberti M et al. Graft-versus-host-disease after bone marrow transplantation for thalassemia: an analysis of incidence and risk factors. Transplantation 1997; 63: 854–860.

    Article  CAS  Google Scholar 

  4. Goulmy E, Schipper R, Pool J et al. Mismatches of minor histocompatibility antigens between HLA-identical donors and recipients and the development of graft-versus-host disease after bone marrow Transplantation. N Engl J Med 1996; 334: 281–285.

    Article  CAS  Google Scholar 

  5. Mutis T, Gillespie G, Schrama E et al. Tetrameric HLA class I-minor histocompatibility antigen peptide complexes demonstrate minor istocompatibility antigen-specific cytotoxic T lymphocytes in patients with graft-versus-host disease. Nat Med 1999; 5: 839–842.

    Article  CAS  Google Scholar 

  6. den Haan JMM, Meadows LM, Wang W et al. The minor histocompatibility antigen HA-1: a diallelic gene with a single amino acid polymorphism. Science 1998; 279: 1054–1057.

    Article  CAS  Google Scholar 

  7. Lin MT, Gooley T, Hansen JA et al. Absence of statistically significant correlation between disparity for the minor histocompatibility antigen HA-1 and outcome after allogeneic hematopoietic cell transplantation. Blood 2001; 98: 317–3173.

    Article  Google Scholar 

  8. Thomas ED, Storb R, Clift RA et al. Bone marrow transplantation. N Engl J Med 1975; 292: 832–843.

    Article  CAS  Google Scholar 

  9. Wilke M, Pool J, den Haan JMH, Goulmy E . Genomic identification of the minor histocompatibility antigen HA-1 locus by allele specific PCR. Tissue Antigens 1998; 52: 312–317.

    Article  CAS  Google Scholar 

  10. Kurz B, Steiert I, Heuchert G et al. New high resolution typing strategy for HLA-A locus alleles based on dye terminator sequencing of haplotypic group-specific PCR-amplicons of exon 2 and exon 3. Tissue Antigens 1999; 53: 81–96.

    Article  CAS  Google Scholar 

  11. Tseng LH, Lin MT, Martin PJ et al. Definition of the gene encoding the minor histocompatibility antigen HA-1 and typing for HA-1 from genomic DNA. Tissue Antigens 1998; 52: 305–311.

    Article  CAS  Google Scholar 

  12. Van Els CA, D’Amaro J, Pool J et al. Immunogenetics of human minor histocompatibility antigens: their polymorphism and immunodominance. Immunogenetics 1992; 35: 161–655.

    Article  CAS  Google Scholar 

  13. Tseng LH, Lin MT, Hansen JA et al. Correlation between disparity for the minor histocompatibility antigen HA-1 and the development of acute graft versus host disease after allogeneic marrow transplantation. Blood 1999; 94: 2911–2914.

    CAS  Google Scholar 

  14. Gallardo D, Arostegui JI, Balas A et al. Disparity for the minor histocompatibility antigen HA-1 is associated with an increased risk of acute graft versus host disease (GVHD) but it does not affect chronic GVHD incidence, disease-free-survival or overall survival after allogeneic human leucocyte antigen-identical sibling donor transplantation. Br J Haematol 2001; 114: 931–936.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dipartimento di Onco Ematologia, Laboratorio di Ricerca Onco-Ematologico, Pesaro, Italy

    S Nesci, O Buffi, A Iliescu & M Andreani

  2. Unità Operativa di Ematologia, Centro Trapianti di Midollo Osseo di Muraglia, Azienda Ospedaliera S. Salvatore di Pesaro, Italy

    G Lucarelli

Authors
  1. S Nesci
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. O Buffi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A Iliescu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M Andreani
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. G Lucarelli
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nesci, S., Buffi, O., Iliescu, A. et al. Recipient mHag-HA1 disparity and aGVHD in thalassemic-transplanted patients. Bone Marrow Transplant 31, 575–578 (2003). https://doi.org/10.1038/sj.bmt.1703880

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1703880

Keywords

This article is cited by

Search

Advanced search

Quick links