Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Mycosis Fungoides

Treatment of advanced mycosis fungoides by allogeneic stem-cell transplantation with a nonmyeloablative regimen

Bone Marrow Transplantation volume 31, pages 663–666 (2003)Cite this article

Summary:

Given the poor prognosis of patients with advanced cutaneous T-cell lymphoma and the high transplant-related mortality associated with conventional allogeneic bone marrow transplantation, we performed nonmyeloablative transplantation of allogeneic stem cells (ASCT) from HLA-identical siblings in three patients with this disease. All patients achieved full donor engraftment, clearance of clonal T cells leading to durable complete remissions but experienced high incidence of infections, which proved fatal in one case. These results suggest that nonmyeloablative ASCT is a novel and potentially curative therapy for patients with advanced T-cell lymphomas who have a histocompatible sibling.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2

Similar content being viewed by others

References

  1. Diamandidou E, Cohen PR, Kurzrock R . Mycosis fungoides and Sézary syndrome. Blood 1996; 88: 2385–2409.

    CAS  Google Scholar 

  2. Siegel RS, Pandlfino T, Guitart J et al. Primary cutaneous T-cell lymphoma: review and current concepts. J Clin Oncol 2000; 18: 2908–2925.

    Article  CAS  Google Scholar 

  3. De Coninck EC, Kim YH, Varghese A, Hoppe R . Clinical characteristics and outcome of patients with extracutaneous mycosis fungoides. J Clin Oncol 2001; 19: 779–784.

    Article  CAS  Google Scholar 

  4. Bigler RD, Crilley P, Micaily B et al. Autologous bone marrow transplantation for advanced stage mycosis fungoides. Bone Marrow Transplant 1991; 7: 133–137.

    CAS  Google Scholar 

  5. Sterling JC, Marcus R, Burrows NP, Roberts SO . Erythrodermic mycosis fungoides treated with total body irradiation and autologous bone marrow transplantation. Clin Exp Dermatol 1995; 20: 73–75.

    Article  CAS  Google Scholar 

  6. Olavarria E, Child F, Woolford A et al. T-cell depletion and autologous stem cell transplantation in the management of tumor stage mycosis fungoides with peripheral blood involvement. Br J Haematol 2001; 114: 624–631.

    Article  CAS  Google Scholar 

  7. Guitart BRK, Traynor A, Link C et al. Allogenic hematopoietic stem cell transplantation for advanced mycosis fungoides: evidence of a graft-versus-tumor effect. Bone Marrow Transplant 2000; 25: 111–113.

    Article  Google Scholar 

  8. Molina A, Nademanee A, Arber DA, Forman SJ . Remission of refractory Sezary syndrome after bone marrow transplantation from a matched unrelated donor. Biol Blood Marrow Transplant 1999; 5: 400–404.

    Article  CAS  Google Scholar 

  9. Molina A, Arber D, Murata-Collins JL et al. Clinical, cytogenetic and molecular remissions after allogeneic hematopoietic stem cell transplantation (HSCT) for refractory Sezary syndrome and tumor-stage mycosis fungoides. Blood 2001; 98: 409a.

    Google Scholar 

  10. Cordell J, Falini B, Erber WN et al. Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes). J Histochem Cytochem 1984; 32: 219–229.

    Article  CAS  Google Scholar 

  11. Bottaro M, Berti E, Biondi A et al. Heteroduplex analysis of T-cell γ gene rearrangements for diagnosis and monitoring of cutaneous T-cell lymphomas. Blood 1994; 83: 3271–3278.

    CAS  PubMed  Google Scholar 

  12. Pindolia K, Janakiraman N, Kasten-Sportes C et al. Enhanced assessment of allogenic bone marrow transplantation using automated fluorescent-based typing. Bone Marrow Transplant 1999; 24: 1235–1241.

    Article  CAS  Google Scholar 

  13. Vonderheid EC, Bernengo MG, Burg G et al. Update on the erythrodermic cutaneous T-cell lymphoma: report of the International Society for Cutaneous Lymphomas. J Am Acad Dermatol 2002; 45: 95–105.

    Article  Google Scholar 

  14. Morolleau JP, Bacard M, Flageul B et al. High-dose recombinant interleukin-2 in advanced cutaneous T-cell lymphoma. Arch Dermatol 1995; 131: 574–579.

    Article  Google Scholar 

  15. Saleh MN, LeMaistre CF, Kuzel TM et al. Antitumor activity of DAB389IL-2 fusion toxin in mycosis fungoides. J Am Acad Dermatol 1998; 39: 63–73.

    Article  CAS  Google Scholar 

  16. Slavin S, Nagler A, Naparstek E et al. Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cyto-reduction for the treatment of malignant and nonmalignant hematologic diseases. Blood 1998; 91: 756–763.

    CAS  Google Scholar 

  17. Khouri IF, Keating M, Korbling M et al. Transplant-lite: induction of graft-versus-malignancy using fludarabine-based nonablative chemotherapy and allogenic blood progenitor-cell transplantation as treatment for lymphoid malignancies. J Clin Oncol 1998; 16: 2817.

    Article  CAS  Google Scholar 

  18. Scarisbrick JJ, Child FJ, Clift A et al. A trial of fludarabine and cyclophosphamide combination therapy in the treatment of advanced refractory primary cutaneous T-cell lymphoma. Br J Haematol 2001; 144: 1010–1015.

    CAS  Google Scholar 

  19. Cooper DL, Braverman IM, Sarris AH et al. Cyclosporine treatment of refractory T-cell lymphomas. Cancer 1993; 71: 2335–2341.

    Article  CAS  Google Scholar 

  20. Tsambiras PE, Patel S, Greene JN et al. Infectious complications of cutaneous T-cell lymphoma. Cancer Control 2001; 8: 185–188.

    Article  CAS  Google Scholar 

  21. Axelrod PI, Lorber B, Vonderheid EC . Infections complicating mycosis fungoides and Sézary syndrome. JAMA 1992; 267: 1354–1358.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Hematology, IRCCS Ospedale Maggiore, Milano, Italy

    D Soligo, A Ibatici, P Morandi, C Annaloro, L Robbiolo, A Della Volpe & G Lambertenghi Deliliers

  2. Department of Dermatology, IRCCS Ospedale Maggiore, Milano, Italy

    E Berti, L Venegoni & E Alessi

  3. Transplantation Immunology and Blood Transfusion Services, IRCCS Ospedale Maggiore, Milano, Italy

    E Longhi

  4. Institute of Infectious and Tropical Diseases, University of Milano, Milano, Italy

    M Corbellino

Authors
  1. D Soligo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A Ibatici
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E Berti
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P Morandi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. E Longhi
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. L Venegoni
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. M Corbellino
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. C Annaloro
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. L Robbiolo
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. A Della Volpe
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. E Alessi
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. G Lambertenghi Deliliers
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Soligo, D., Ibatici, A., Berti, E. et al. Treatment of advanced mycosis fungoides by allogeneic stem-cell transplantation with a nonmyeloablative regimen. Bone Marrow Transplant 31, 663–666 (2003). https://doi.org/10.1038/sj.bmt.1703872

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1703872

Keywords

This article is cited by

Search

Advanced search

Quick links