Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Post-transplant Complications

Total energy expenditure and body composition changes following peripheral blood stem cell transplantation and participation in an exercise programme

Bone Marrow Transplantation volume 31, pages 331–338 (2003)Cite this article

Summary:

The purpose of this investigation was to assess changes in total energy expenditure (TEE), body weight (BW) and body composition following a peripheral blood stem cell transplant and following participation in a 3-month duration, moderate-intensity, mixed-type exercise programme. The doubly labelled and singly labelled water methods were used to measure TEE and total body water (TBW). Body weight and TBW were then used to calculate percentage body fat (%BF), and fat and fat-free mass (FFM). TEE and body composition measures were assessed pretransplant (PI), immediately post-transplant (PII) and 3 months post-PII (PIII). Following PII, 12 patients were divided equally into a control group (CG) or exercise intervention group (EG). While there was no change in TEE between pre- and post-transplant, BW (P<0.01) and FFM (P<0.05) significantly decreased during the same period. Participation in the exercise programme led to increases in TEE to levels that were both higher than pre- and post-transplant measures (P<0.01). By PIII, the exercising patients also showed gains in FFM (P<0.01) in association with a reduction in %BF (P<0.05). Exercise has a functionally important role in preserving and increasing skeletal mass in the rehabilitation phase of cancer patients.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1

Similar content being viewed by others

References

  1. Inui A . Cancer anorexia-cachexia syndrome: are neuropeptides the key? Cancer Res 1999; 59: 4493–4501.

    CAS  PubMed  Google Scholar 

  2. Chapman KM, Nelson RA . Loss of appetite: managing unwanted weight loss in the older patient. Geriatrics 1994; 49: 54–59.

    CAS  PubMed  Google Scholar 

  3. Falconer JS, Fearon KCH, Plester CE et al. Cytokines the acute-phase response, and resting energy expenditure in cachectic patients with pancreatic cancer. Ann Surg 1994; 219: 325–331.

    Article  CAS  Google Scholar 

  4. Davies PSW . Measurement of energy expenditure and body composition using stable isotopes. Dev Physiopathol Clin 1991; 2: 95–110.

    Google Scholar 

  5. Kutynec CL, McCargar L, Barr SI, Hislop GT . Energy balance in women with breast cancer during adjuvant treatment. J Am Diet Assoc 1999; 99: 1222–1227.

    Article  CAS  Google Scholar 

  6. Jebb SA . Energy metabolism in cancer and human immunodeficiency virus infection. Proc Nutr Soc 1997; 56: 763–775.

    Article  CAS  Google Scholar 

  7. Warner JT, Bell W, Webb DKH, Gregory JW . Daily energy expenditure and physical activity in survivors of childhood malignancy. Pediatr Res 1998; 43: 607–613.

    Article  CAS  Google Scholar 

  8. Charuhas PM, Rosenberg K, Bruemmer B et al. A double-blind randomized trial comparing outpatient parenteral nutrition with intravenous hydration effect on resumption of oral intake after marrow transplantation. J Parenteral Enteral Nutr 1997; 21: 157–161.

    Article  CAS  Google Scholar 

  9. Jebb SA, Osborne RJ, Dixon AK et al. Measurements of resting energy expenditure and body composition before and after treatment of small cell lung cancer. Ann Oncol 1994; 5: 915–919.

    Article  CAS  Google Scholar 

  10. Davies PSW, Wells JCK . Calculation of total body water in infancy. Eur J Clin Nutr 1994; 48: 490–495.

    CAS  PubMed  Google Scholar 

  11. Halliday D, Miller AG . Precise measurement of total body water using trace quantities of deuterium oxide. Biomed Mass Spectrom 1977; 4: 82–89.

    Article  CAS  Google Scholar 

  12. Simons JP, Schols AM, Hoefnagels JMJ et al. Effects of medroxyprogesterone acetate on food intake, body composition, and resting energy expenditure in patients with advanced, nonhormone-sensitive cancer. Cancer 1998; 82: 553–560.

    Article  CAS  Google Scholar 

  13. Schoeller DA, Fjeld CR . Human energy metabolism: what have we learned from the doubly labeled water method? Annu Rev Nutr 1991; 11: 355–373.

    Article  CAS  Google Scholar 

  14. Davies PSW, Ewing G, Lucas A . Energy expenditure in early infancy. Br J Nutr 1989; 62: 621–629.

    Article  CAS  Google Scholar 

  15. Weir JD . New methods for calculating metabolic rate with special reference to protein metabolism. J Physiol 1949; 109: 1–9.

    Article  Google Scholar 

  16. Davies PSW, Cameron JE, Lucas A . Reference Data for Total Energy Expenditure in Early Infancy. EDECG Publication: Switzerland, 1990.

    Google Scholar 

  17. Keys A, Brozek J, Henschel O et al. The Biology of Human Starvation. University of Minnesota Press: Minneapolis, 1950.

    Book  Google Scholar 

  18. Sakurai Y, Klein S . Metabolic alteration in patients with cancer: nutritional implications. Surg Today 1998; 28: 247–257.

    Article  CAS  Google Scholar 

  19. Brennan MJ, DePompolo RW, Garden FH . Cardiovascular, pulmonary, and cancer rehabilitation. 3. Cancer rehabilitation. Arch Phys Med Rehab 1996; 77: S52–S65.

    Article  CAS  Google Scholar 

  20. Demark-Wahnefried W, Peterson B, McBride C et al. Current health behaviors and readiness to pursue life-style changes among men and women diagnosed with early stage prostate and breast carcinomas. Cancer 2000; 88: 674–684.

    Article  CAS  Google Scholar 

  21. Taskinen M, Saarinen UM . Skeletal muscle protein reserve after bone marrow transplantation in children. Bone Marrow Transplant 1996; 18: 937–941.

    CAS  PubMed  Google Scholar 

  22. Mulligan K, Bloch AS . Energy expenditure and protein metabolism in human immunodeficiency virus infection and cancer cachexia. Semin Oncol 1998; 25 (Suppl. 6): 82–89.

    CAS  PubMed  Google Scholar 

  23. Tisdale MJ . Cancer cachexia: metabolic alterations and clinical manifestations. Nutrition 1997; 13: 1–7.

    Article  CAS  Google Scholar 

  24. Ogilvie GK . Interventional nutrition for the cancer patient. Clin Techn Small Anim Pract 1998; 13: 224–231.

    Article  CAS  Google Scholar 

  25. Goran MI, Poehlman ET . Total energy expenditure and energy requirements in healthy elderly persons. Metabolism 1992; 41: 744–753.

    Article  CAS  Google Scholar 

  26. Dimeo F, Fetscher S, Lange W et al. An aerobic exercise program for patients with haematological malignancies after bone marrow transplantation. Bone Marrow Transplant 1996; 18: 1156–1160.

    Google Scholar 

  27. Courneya KS, Keats MR, Turner RA . Physical exercise and quality of life in cancer patients following high dose chemotherapy and autologous bone marrow transplantation. Psycho-Oncology 2000; 9: 127–136.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We are indebted to the 12 committed patients who made this study possible. This study was supported in part by the National Breast Cancer Foundation, Australia.

Author information

Authors and Affiliations

  1. School of Human Movements Studies, Faculty of Health, Queensland University of Technology, Brisbane, 4059, Queensland, Australia

    S Hayes & T Parker

  2. Centre for Public Health Research, Faculty of Health, Queensland University of Technology, Brisbane, 4059, Queensland, Australia

    S Hayes

  3. Department of Pediatrics and Child Health, Children's Nutrition Research Centre, University of Queensland, Royal Children's Hospital, Brisbane, 4029, Queensland, Australia

    P S W Davies

  4. The Wesley Hospital, Brisbane, Queensland, Australia

    J Bashford

Authors
  1. S Hayes
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. P S W Davies
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T Parker
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J Bashford
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hayes, S., Davies, P., Parker, T. et al. Total energy expenditure and body composition changes following peripheral blood stem cell transplantation and participation in an exercise programme. Bone Marrow Transplant 31, 331–338 (2003). https://doi.org/10.1038/sj.bmt.1703867

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1703867

Keywords

This article is cited by

Search

Advanced search

Quick links