Summary:
A 25-year-old male developed lymphoid blast crisis (BC) of chronic myelogenous leukemia (CML) more than 11 years after receiving an allogeneic bone marrow transplant (alloBMT) for CML with myeloid BC at presentation from his HLA-identical brother. The lymphoid BC of CML probably occurred without a preceding chronic phase of CML. This case illustrates the difficulties involved in determining the appropriate length of follow-up after alloBMT.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Cooley LD, Sears DA, Udden MM et al. Donor cell leukemia: report of a case occurring 11 years after allogeneic bone marrow transplantation and review of the literature. Am J Hematol 2000; 63: 46–53.
Sill H, Goldman JM, Cross NC . Homozygous deletions of the p16 tumor-suppressor gene are associated with lymphoid transformation of chronic myeloid leukemia. Blood 1995; 85: 2013–2016.
Serra A, Gottardi E, Della Ragione F et al. Involvement of the cyclin-dependent kinase-4 inhibitor (CDKN2) gene in the pathogenesis of lymphoid blast crisis of chronic myelogenous leukaemia. Br J Haematol 1995; 91: 625–629.
Dhingra K, Talpaz M, Kantarjian H et al. Appearance of acute leukemia-associated p190 bcr–abl in chronic myelogenous leukemia may correlate with disease progression. Leukemia 1991; 5: 191–195.
Morgan GJ, Hernandez A, Chan LC et al. The role of alternative splicing patterns of BCR/ABL transcripts in the generation of the blast crisis of chronic myeloid leukaemia. Br J Haematol 1990; 76: 33–38.
Lichty BD, Keating A, Callum J et al. Expression of p210 and p190 bcr–abl due to alternative splicing in chronic myelogenous leukaemia. Br J Haematol 1998; 103: 711–715.
van Rhee F, Hochhaus A, Lin F et al. p190 bcr–abl mRNA is expressed at low levels in p210-positive chronic myeloid and acute lymphoblastic leukemias. Blood 1996; 87: 5213–5217.
Radich JP, Gehly G, Gooley T et al. Polymerase chain reaction detection of the bcr–abl fusion transcript after allogeneic marrow transplantation for chronic myeloid leukemia: results and implications in 346 patients. Blood 1995; 85: 2632–2638.
van Rhee F, Lin F, Cross NCP et al. Detection of residual leukemia more than 10 years after allogeneic bone marrow transplantation for chronic myelogenous leukaemia. Bone Marrow Transplant 1994; 14: 609–612.
Yong ASM, Goldman JM . Relapse of chronic myeloid leukaemia 14 years after allogeneic bone marrow transplantation. Bone Marrow Transplant 1999; 23: 827–828.
Lin F, van Rhee F, Goldman JM, Cross NCP . Kinetics of increasing bcr–abl transcript numbers in chronic myeloid leukemia patients who relapse after bone marrow transplantation. Blood 1996; 87: 4473–4478.
Kolb HJ, Schattenberg A, Goldman JM et al. Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. Blood 1995; 86: 2041–2050.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Fukuno, K., Tsurumi, H., Yamada, T. et al. Lymphoid blast crisis of chronic myelogenous leukemia occurring more than 11 years after receiving an allogeneic bone marrow transplant for chronic myelogenous leukemia in myeloid blast crisis at onset. Bone Marrow Transplant 31, 211–213 (2003). https://doi.org/10.1038/sj.bmt.1703820
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1703820
