Abstract
The β-herpesviruses, human herpesviruses-6 and -7 (HHV-6 and HHV-7), are closely related and have very similar biological behaviour. While HHV-6 is associated with encephalitis in immunosuppressed adults, HHV-7 is not recognised as a cause of neurological disease in such patients. This report describes the identification of a reactivated HHV-7 infection in the cerebrospinal fluid of an adult who presented with an acute myelitis 11 months after unrelated donor bone marrow transplant.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Gallardo D, Ferrà C, Berlanga JJ et al. Neurologic complications after allogeneic bone marrow transplantation Bone Marrow Transplant 1996 18: 1135 1139
Graus F, Saiz A, Sierrra J et al. Neurologic complications of autologous and allogeneic bone marrow transplantation in patients with leukaemia: a comparative study Neurology 1996 46: 1004 1009
Braun DK, Domingues G, Pellet PE . Human herpesvirus 6 Clin Micro Rev 1997 10: 521 567
Black JB, Pellet PE . Human herpesvirus 7 Rev Med Virol 1999 9: 245 262
Van den Berg JSP, Van Zeijl JH, Rotteveel JJ et al. Neuroinvasion by human herpesvirus type 7 in a case of exanthem subitum with severe neurologic manifestations Neurology 1999 52: 1077 1079
McCullers JA, Lakeman FD, Whitley RJ . Human herpesvirus 6 is associated with focal encephalitis Clin Infect Dis 1996 21: 571 576
Singh N, Paterson DL . Encephalitis caused by human herpesvirus-6 in transplant recipients. Relevance of a novel neurotropic virus Transplantation 2000 69: 2474 2479
Ward KN, Kalima P, MacLeod KM, Riordan T . Neuroinvasion during delayed primary HHV-7 infection in an immunocompetent adult with encephalitis and flaccid paralysis J Med Virol 2002 67: 538 541
Kottaridis PD, Milligan DW, Chopra R et al. In vivo CAMPATH-1H prevents graft-versus-host disease following nonmyeloablative stem cell transplantation Blood 2000 96: 2419 2425
Kidd IM, Clark DA, Bremner JAG et al. A multiplex PCR assay for the simultaneous detection of human herpesvirus 6 and human herpesvirus 7, with typing of HHV-6 by enzyme cleavage of PCR products J Virol Methods 1998 70: 29 36
Ward KN, Turner DJ, Couto Parada X, Thiruchelvam AD . Use of immunoglobulin G antibody avidity for differentiation of primary human herpesvirus-6 and -7 infections J Clin Microbiol 2001 39: 959 963
Peggs KS, Preiser W, Kottaridis PD et al. Extended routine polymerase chain reaction surveillance and pre-emptive antiviral therapy for cytomegalovirus after allogeneic transplantation Br J Haematol 2000 111: 782 790
Griffin DE . Encephalitis, myelitis and neuritis In: Mandell GL, Bennett JE, Dolin R (eds) Principles and Practice of Infectious Diseases, 5th edn Churchill Livingstone: Philadelphia 2000 p 1012
Chan PK, Peiris JS, Yuen KY et al. Human herpesvirus-6 and human herpesvirus-7 infections in bone marrow transplant recipients J Med Virol 1997 53: 295 305
Wang FZ, Dahl H, Linde A et al. Lymphotropic herpesviruses in allogeneic bone marrow transplantation Blood 1996 88: 3615 3620
Chan PKS, Ng HK, Hui M et al. Presence of human herpesviruses 6, 7 and 8 DNA sequences in normal brain tissue J Med Virol 1999 59: 491 495
Chan PKS, Ng HK, Cheung JL et al. Prevalence and distribution of human herpesvirus 7 in normal brain J Med Virol 2000 62: 345 348
Wang F-Z, Linde A, Hägglund H et al. Human herpesvirus 6 DNA in cerebrospinal fluid specimens from allogeneic bone marrow transplants: does it have clinical significance? Clin Infect Dis 1999 28: 562 568
Zhang Y, Schols D, De Clercq E . Selective activity of various antiviral compounds against HHV-7 infection Antiviral Res 1999 43: 23 35
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ward, K., White, R., Mackinnon, S. et al. Human herpesvirus-7 infection of the CNS with acute myelitis in an adult bone marrow recipient. Bone Marrow Transplant 30, 983–985 (2002). https://doi.org/10.1038/sj.bmt.1703774
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1703774
Keywords
This article is cited by
-
Case Report of a Malignant Melanoma Patient with Longitudinally Extensive Transverse Myelitis: Immune-Related Adverse Event or Human Herpesvirus-7 Infection?
SN Comprehensive Clinical Medicine (2022)
-
Molecular detection of human herpesvirus 7 DNA in cerebrospinal fluid from adult patients with neurological disorders
Journal of NeuroVirology (2018)
-
Encephalitis associated with human herpesvirus-7 infection in an immunocompetent adult
Virology Journal (2017)
-
Opportunistic Infections of the Central Nervous System in the Transplant Patient
Current Neurology and Neuroscience Reports (2013)