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Voriconazole in the management of invasive aspergillosis in two patients with acute myeloid leukemia undergoing stem cell transplantation

Bone Marrow Transplantation volume 30, pages 967–970 (2002)Cite this article

Abstract

The management of invasive aspergillosis in patients with hematological malignancies remains controversial. A major problem is how to manage patients who had invasive aspergillosis during remission induction and consolidation therapy and then undergo SCT. Indeed in these patients the mortality rate related to invasive aspergillosis recurrence remains unacceptably high. We report two cases of patients who underwent remission induction for AML, developed invasive aspergillosis during antifungal prophylaxis with itraconazole, failed amphotericin B deoxycholate and liposomal amphotericin B treatment, were successfully treated with voriconazole and eventually underwent SCT with voriconazole prophylaxis without reactivation of invasive aspergillosis.

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Acknowledgements

Voriconazole was supplied as compassionate treatment by Pfizer Central Research, Sandwich, UK.

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Authors and Affiliations

  1. Hematology Department, S Croce Hospital, Cuneo, Italy

    D Mattei, N Mordini, C Lo Nigro & A Gallamini

  2. Radiology Department, S Croce Hospital, Cuneo, Italy

    D Ghirardo

  3. Laboratory Department, S Croce Hospital, Cuneo, Italy

    MT Ferrua & M Osenda

  4. Hematology Department, S Martino Hospital, Genoa, Italy

    A Bacigalupo

  5. National Cancer Institute, Genoa, Italy

    C Viscoli

Authors
  1. D Mattei
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  2. N Mordini
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Mattei, D., Mordini, N., Lo Nigro, C. et al. Voriconazole in the management of invasive aspergillosis in two patients with acute myeloid leukemia undergoing stem cell transplantation. Bone Marrow Transplant 30, 967–970 (2002). https://doi.org/10.1038/sj.bmt.1703763

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  • DOI: https://doi.org/10.1038/sj.bmt.1703763

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