Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Case Report
  • Published:

Recovery of renal function after autologous stem cell transplantation in myeloma patients with end-stage renal failure

Bone Marrow Transplantation volume 30, pages 471–473 (2002)Cite this article

Abstract

The disease-free survival of patients with myeloma and severe renal failure after high-dose melphalan and autologous stem cell rescue is similar to those with normal renal function at the time of the autograft. However, recovery of renal function after intensive treatment is uncommon and patients with end-stage renal failure continue to be dialysis-dependent. We report two patients with myeloma who required regular haemodialysis from diagnosis, but became dialysis-independent after a high-dose melphalan autograft. Thus, in some patients, renal function may be partially salvageable despite the requirement for dialysis at the time of autografting.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Badros A, Barlogie B, Siegel E et al. Results of autologous stem cell transplant in multiple myeloma patients with renal failure Br J Haematol 2001 114: 822 829

    Article  CAS  Google Scholar 

  2. Sirohi B, Powles R, Kulkarni S et al. Glomerular filtration rate prior to high-dose melphalan 200 mg/m2 as a surrogate marker of outcome in patients with myeloma Br J Cancer 2001 85: 325 332

    Article  CAS  Google Scholar 

  3. Sirohi B, Powles R, Treleaven J et al. The implication of compromised renal function at the time of presentation in myeloma: a single centre study of 251 patients Blood 1999 94: (Suppl. 1) 575a

    Google Scholar 

  4. Alexanian R, Barlogie B, Dixon D . Renal failure in myeloma. Pathogenesis and prognostic implications Arch Intern Med 1990 150: 1693 1695

    Article  CAS  Google Scholar 

  5. Ballester OF, Tummala R, Jansen WE et al. High-dose chemotherapy and autologous peripheral blood stem cell transplantation in patients with multiple myeloma and renal insufficiency Bone Marrow Transplant 1997 20: 653 656

    Article  CAS  Google Scholar 

  6. Sirohi B, Powles R, Kulkarni S et al. Feasibility of administering high-dose melphalan (HDM) with autotransplantation in myeloma patients on dialysis Blood 2001 98: 5381 (Abstr.)

    Google Scholar 

  7. Goldschmidt H, Lannert H, Bommer J et al. Multiple myeloma and renal failure Nephrol Dial Transplant 2000 15: 301 304

    Article  CAS  Google Scholar 

  8. Powles R, Raje N, Milan S et al. Outcome assessment of a population based group of 195 unselected myeloma patients under 70 years of age offered intensive treatment Bone Marrow Transplant 1997 20: 435 443

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Bone Marrow Transplant Unit, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK

    S Tauro, FJ Clark, N Duncan & P Mahendra

  2. Department of Nephrology, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK

    G Lipkin & N Richards

Authors
  1. S Tauro
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. FJ Clark
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. N Duncan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. G Lipkin
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. N Richards
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. P Mahendra
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tauro, S., Clark, F., Duncan, N. et al. Recovery of renal function after autologous stem cell transplantation in myeloma patients with end-stage renal failure. Bone Marrow Transplant 30, 471–473 (2002). https://doi.org/10.1038/sj.bmt.1703713

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1703713

Keywords

This article is cited by

Search

Advanced search

Quick links