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Successful hematopoietic stem cell transplantation for aplastic anemia following living-related liver transplantation

Bone Marrow Transplantation volume 30, pages 531–534 (2002)Cite this article

Abstract

A 1-year-old boy received a living–related liver transplantation (LRLT) from his HLA-haploidentical father to treat acute liver failure following non-A, non-B, non-C hepatitis. He subsequently developed pancytopenia and was diagnosed with aplastic anemia (AA). He was platelet transfusion dependent and developed two episodes of life-threatening intracranial hemorrhage despite immuno-suppressive therapy consisting of cyclosporin A, antithymocyte globulin, and anabolic steroids. He received combined hematopoietic stem cell transplantation (hSCT) with cord blood and bone marrow from an HLA-matched sibling. Conditioning consisted of cyclophosphamide (CY) 200 mg/kg and 7 Gy total lymphoid irradiation (TLI). Marrow engraftment was prompt and there was no significant graft-versus-host disease (GVHD).

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Authors and Affiliations

  1. Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan

    K Umeda, S Adachi, K Watanabe, N Kimura, Y Lin & T Nakahata

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  1. K Umeda
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  2. S Adachi
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  3. K Watanabe
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  4. N Kimura
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  5. Y Lin
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  6. T Nakahata
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Umeda, K., Adachi, S., Watanabe, K. et al. Successful hematopoietic stem cell transplantation for aplastic anemia following living-related liver transplantation. Bone Marrow Transplant 30, 531–534 (2002). https://doi.org/10.1038/sj.bmt.1703689

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  • DOI: https://doi.org/10.1038/sj.bmt.1703689

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