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Cytokine Polymorphisms

Polymorphisms of transforming growth factor-β1 and transforming growth factor-β1 type II receptor genes are associated with acute graft-versus-host disease in children with HLA-matched sibling bone marrow transplantation

Bone Marrow Transplantation volume 30, pages 665–671 (2002)Cite this article

Abstract

The aim of this study was to determine whether the gene polymorphisms of Th1/Th2 and immunoregulatory cytokines were associated with aGVHD in Japanese children receiving allogeneic bone marrow transplantation (allo BMT). We investigated polymorphisms of genes encoding interleukin (IL)-4, IL-4 receptor (IL-4 R), IL-10, transforming growth factor (TGF)-β1, TGF-β1 type II receptor (TGF-β1 RII), interferon (IFN)-γ, IFN-γ type 2 receptor (IFN-γ R2), and IFN regulatory factor (IRF)-1. Sixty-seven patients were treated with alloBMT from HLA-identical siblings, and aGVHD was observed in 38. TGF-β1 codon 10 leucine (Leu) /proline (Pro) polymorphism in donors was associated with the development of aGVHD. Patients having donors with the Pro allele had aGVHD more frequently than those without Pro allele (30/45 vs 8/20, odds ratio = 3.00; P = 0.04). TGF-β1 RII 1167 C/T polymorphism in recipients was also associated with the development of aGVHD. The incidence was significantly higher in recipients with T allele than in those without T allele (21/27 vs 16/35, odds ratio = 4.16; P = 0.01). In conclusion, genetic backgrounds of TGF-β1 and TGF-β1 RII may be involved in the development of aGVHD in HLA-matched sibling BMT in Japanese children.

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Acknowledgements

We thank Naoko Kinukawa, PhD, the Department of Medical Informatics, Graduate School of Medical Sciences, Kyushu University, for the valuable advice on the statistical analysis, and Ms Tamami Tanaka and Ms Yoko Katafuchi for their excellent technical assistance.

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Authors and Affiliations

  1. Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    H Hattori, A Matsuzaki, A Suminoe, K Ihara & T Hara

  2. Division of Child Health, School of Health Sciences, Kyushu University, Fukuoka, Japan

    A Matsuzaki

  3. Section of Pediatrics, National Kyushu Cancer Center, Fukuoka, Japan

    Y Nagatoshi

  4. Institute for Clinical Research, National Kyushu Cancer Center, Fukuoka, Japan

    H Hattori & J Okamura

  5. Department of Pediatrics, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan

    N Sakata & K Kawa

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Hattori, H., Matsuzaki, A., Suminoe, A. et al. Polymorphisms of transforming growth factor-β1 and transforming growth factor-β1 type II receptor genes are associated with acute graft-versus-host disease in children with HLA-matched sibling bone marrow transplantation. Bone Marrow Transplant 30, 665–671 (2002). https://doi.org/10.1038/sj.bmt.1703684

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