Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Case Report
  • Published:

Acute myocardial ischemia after high-dose therapy with BEAM regimen

Abstract

We describe a case of acute myocardial ischemia following carmustine treatment during the BEAM regimen. Despite this, full completion of the autologous peripheral stem-cell transplant was possible.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Salloun E, Jillella AP, Nadkarni R et al. Assessment of pulmonary and cardiac function after high dose chemotherapy with BEAM and peripheral blood progenitor cell transplantation Cancer 1998 82: 1506 1512

    Article  Google Scholar 

  2. Kanj SS, Sharara AI, Shpall EJ et al. Myocardial ischemia associated with high-dose carmustine infusion Cancer 1991 68: 1910 1912

    Article  CAS  Google Scholar 

  3. Takvorian T, Parker LM, Hochberg FH et al. Autologous bone marrow transplantation: host effects of high-dose BCNU J Clin Oncol 1983 1: 610 620

    Article  CAS  Google Scholar 

  4. Phillips GL, Fay JW, Herzig GP et al. Intensive 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), NSC#4366650 and cryopreserved autologous marrow transplantation for refractory cancer. A phase I–II study Cancer 1983 55: 1792 1802

    Article  Google Scholar 

  5. Henner W, Peters WP, Eder JP et al. Pharmacokinetics and immediate effects of high-dose carmustine in man Cancer Treat Rep 1986 70: 877 880

    CAS  PubMed  Google Scholar 

  6. Van Besien K, Tabacoff J, Rodriguez M et al. High-dose chemotherapy with BEAC regimen and autologous bone marrow transplantation for intermediate grade and immunoblastic lymphoma: durable complete remissions, but a high rate of regimen-related toxicity Bone Marrow Transplant 1995 15: 549 555

    CAS  Google Scholar 

  7. Peters WP, Roderheaver DP, Mendel DB et al. Effects of high dose alkylating agents on endomyocardial glutathione levels and cardiac performance Proc Am Assoc Cancer Res 1988 29: 268 273

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Genet, P., Pulik, M., Gallet, B. et al. Acute myocardial ischemia after high-dose therapy with BEAM regimen. Bone Marrow Transplant 30, 253–254 (2002). https://doi.org/10.1038/sj.bmt.1703632

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1703632

Keywords

This article is cited by

Search

Quick links