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Amyloidosis

Toxic megacolon: a life-threatening complication of high-dose therapy and autologous stem cell transplantation among patients with AL amyloidosis

Abstract

AL amyloidosis is a plasma cell disorder in which tissue deposition of immunoglobulin light chains leads to organ dysfunction. Recent reports of high-dose therapy with autologous stem cell transplantation for amyloidosis suggest higher response rates and extended survival compared to those seen with conventional chemotherapy. However, substantial treatment-related toxicity has been observed. This case series describes our institutional experience with autologous transplantation in four patients with amyloidosis with an emphasis on unique gastrointestinal toxicities, including toxic megacolon.

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Acknowledgements

We thank the staff of the Adult Bone Marrow Transplantation Program at Oregon Health and Sciences University, particularly coordinators Anne Kratz, RN and Florence Seelig, RN.

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Hayes-Lattin, B., Curtin, P., Fleming, W. et al. Toxic megacolon: a life-threatening complication of high-dose therapy and autologous stem cell transplantation among patients with AL amyloidosis. Bone Marrow Transplant 30, 279–285 (2002). https://doi.org/10.1038/sj.bmt.1703627

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  • DOI: https://doi.org/10.1038/sj.bmt.1703627

Keywords

  • AL amyloidosis
  • high-dose chemotherapy
  • stem cell transplantation
  • toxic megacolon

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