Abstract
Waldenstrom's macroglobulinemia (WM) is a low-grade lymphoplasmacytoid malignancy of unknown etiology. It primarily affects elderly patients and is characterized by a monoclonal IgM component, varying degrees of cytopenias, lymphadenopathy and manifestations related to hyperviscosity syndromes. WM is usually treated with single agent nucleoside analogues or alkylating agents that often provide high response rates and durable remissions. Recurrence of the disease after primary therapy is not uncommon, and resistance to both alkylating agents and nucleoside analogs eventually emerges. Small numbers of patients have undergone high-dose chemotherapy (HDC) with either autologous (nā=ā24) or allogeneic (nā=ā6) stem cell transplantation (SCT) as treatment for this disease. Most patients in both groups achieved remission. Results are promising and a more in-depth analysis of possible applications of this treatment modality is attempted with this mini-review.
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References
Dimopoulos MA, Panayiotidis P, Moulopoulos LA et al. Waldenstrom's macroglobulinemia: clinical features, complications, and management J Clin Oncol 2000 18: 214 226
Gobbi PG, Bottini R, Montecucco C et al. Study of prognosis in Waldenstrom's macroglobulinemia: a proposal for a simple binary classification with clinical and investigational utility Blood 1994 83: 2939 2945
Facon T, Brouillard M, Duhamel A et al. Prognostic factors in Waldenstrom's macroglobulinemia: a report of 167 cases J Clin Oncol 1993 11: 1553 1558
Dimopoulos MA, Alexanian R . Waldenstrom's macroglobulinemia Blood 1994 83: 1452 1459
Dhodapkar MV, Jacobson JL, Gertz MA et al. Prognostic factors and response to fludarabine therapy in patients with Waldenstrom macroglobulinemia: results of United States intergroup trial (Southwest Oncology Group S9003) Blood 2001 98: 41 48
Legouffe E, Rossi JF, Laporte JP et al. Treatment of Waldenstrom's macroglobulinemia with very low doses of alpha interferon Leuk Lymphoma 1995 19: 337 342
Weide R, Heymanns J, Koppler H . Induction of complete haematological remission after monotherapy with anti-CD20 monoclonal antibody (RITUXIMAB) in a patient with alkylating agent resistant Waldenstrom's macroglobulinaemia Leuk Lymphoma 1999 36: 203 206
Dimopoulos MA, Zomas A, Viniou NA et al. Treatment of Waldenstrom's macroglobulinemia with thalidomide J Clin Oncol 2001 19: 3596 3601
Desikan R, Dhodapkar M, Siegel D et al. High-dose therapy with autologous haemopoietic stem cell support for Waldenstrom's macroglobulinaemia Br J Haematol 1999 105: 993 996
Dreger P, Glass B, Kuse R et al. Myeloablative radiochemotherapy followed by reinfusion of purged autologous stem cells for Waldenstrom's macroglobulinaemia Br J Haematol 1999 106: 115 118
Anagnostopoulos A, Dimopoulos MA, Aleman A et al. High-dose chemotherapy followed by stem cell transplantation in patients with resistant Waldenstrom's macroglobulinemia Bone Marrow Transplant 2001 27: 1027 1029
Moustafa MPJ, Treleaven J, Horton C, Sirohi B . Total therapy with VAMP/CVAMP+ high dose melphalan and autograft for IgM lymphoplasmacytoid disease Blood 1998 92: (Suppl. 1) (Abstr. 4212)
Mazza P, Palazzo G, Amurri B et al. Analysis of feasibility of myeloablative therapy and autologous peripheral stem cell (PBSC) transplantation in the elderly: an interim report Bone Marrow Transplant 1999 23: 1273 1278
Ueda T, Hatanaka K, Kosugi S et al. Successful non-myeloablative allogeneic peripheral blood stem cell transplantation (PBSCT) for Waldenstrom's macroglobulinemia with severe pancytopenia Bone Marrow Transplant 2001 28: 609 611
Yang L, Wen B, Li H et al. Autologous peripheral blood stem cell transplantation for Waldenstrom's macroglobulinemia Bone Marrow Transplant 1999 24: 929 930
Martino R, Shah A, Romero P et al. Allogeneic bone marrow transplantation for advanced Waldenstrom's macroglobulinemia Bone Marrow Transplant 1999 23: 747 749
Dimopoulos MA, Kantarjian H, Weber D et al. Primary therapy of Waldenstrom's macroglobulinemia with 2-chlorodeoxyadenosine J Clin Oncol 1994 12: 2694 2698
Fridrik MA, Jager G, Baldinger C et al. First-line treatment of Waldenstrom's disease with cladribine Ann Hematol 1997 74: 7 10
Dimopoulos MA, Weber D, Delasalle KB et al. Treatment of Waldenstrom's macroglobulinemia resistant to standard therapy with 2-chlorodeoxyadenosine: identification of prognostic factors Ann Oncol 1995 6: 49 52
Delannoy A, van den Neste E, Michaux JL et al. Cladribine for Waldenstrom's macroglobulinaemia Br J Haematol 1999 104: 933 934
Liu ES, Burian C, Miller WE, Saven A . Bolus administration of cladribine in the treatment of Waldenstrom macroglobulinaemia Br J Haematol 1998 103: 690 695
Morel P, Monconduit M, Jacomy D et al. patients with the description of a new scoring system and its validation on 253 other patients Blood 2000 96: 852 858
McLaughlin P, Robertson LE, Keating MJ . Fludarabine phosphate in lymphoma: an important new therapeutic agent Cancer Treat Res 1996 85: 3 14
O'Brien S, Kantarjian H, Beran M et al. Results of fludarabine and prednisone therapy in 264 patients with chronic lymphocytic leukemia with multivariate analysis-derived prognostic model for response to treatment Blood 1993 82: 1695 1700
Ketterer N, Salles G, Moullet I et al. Factors associated with successful mobilization of peripheral blood progenitor cells in 200 patients with lymphoid malignancies Br J Haematol 1998 103: 235 242
Visani G, Lemoli RM, Tosi P et al. Fludarabine-containing regimens severely impair peripheral blood stem cells mobilization and collection in acute myeloid leukaemia patients Br J Haematol 1999 105: 775 779
Michallet M, Thiebaut A, Dreger P . Peripheral blood stem cell (PBSC) mobilization and transplantation after fludarabine therapy in chronic lymphocytic leukaemia (CLL): a report of theEuropean Blood and Marrow Transplantation (EBMT) CLL subcommittee on behalf of the EBMT Chronic Leukaemias Working Party (CLWP) Br J Haematol 2000 108: 595 600
Khouri IF, Keating M, Korbling M et al. Transplant-lite: induction of graft-versus-malignancy using fludarabine- based nonablative chemotherapy and allogeneic blood progenitor-cell transplantation as treatment for lymphoid malignancies J Clin Oncol 1998 16: 2817 2824
Giralt S, Estey E, Albitar M et al. Engraftment of allogeneic hematopoietic progenitor cells with purine analog-containing chemotherapy: harnessing graft-versus-leukemia without myeloablative therapy Blood 1997 89: 4531 4536
McSweeney PA, Niederwieser D, Shizuru JA et al. Hematopoietic cell transplantation in older patients with hematologic malignancies: replacing high-dose cytotoxic therapy with graft-versus- tumor effects Blood 2001 97: 3390 3400
Slavin S, Or R, Aker M, Shapira MY et al. Nonmyeloablative stem cell transplantation for the treatment of cancer and life-threatening nonmalignant disorders: past accomplishments and future goals Cancer Chemother Pharmacol 2001 48: (Suppl. 1) S79 84
van Besien KW, Mehra R, Giralt SA et al. Allogeneic bone marrow transplantation for poor prognosis lymphoma: response, toxicity and survival depend on disease histology Am J Med 1996 100: 299 307
Khouri I, Lee MS, Palmer L et al. Transplant-lite using fludarabine cyclophosphamide and allogeneic stem cell transplant for low grade lymphoma Blood 1999 94: (Suppl. 1) 348a
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Anagnostopoulos, A., Giralt, S. Stem cell transplantation (SCT) for Waldenstrom's macroglobulinemia (WM). Bone Marrow Transplant 29, 943ā947 (2002). https://doi.org/10.1038/sj.bmt.1703580
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DOI: https://doi.org/10.1038/sj.bmt.1703580
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