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Autologous transplantation of CD133 selected hematopoietic progenitor cells in a pediatric patient with relapsed leukemia

Bone Marrow Transplantation volume 29, pages 927–930 (2002)Cite this article

Abstract

A pediatric patient with very early meningeal relapse of his CD34+ CD133− pre-B-ALL was transplanted with 2.5 × 106/kg CD133 selected autologous progenitor cells. Enrichment of CD133+ cells resulted in a purity of 92.3 ± 3.5% CD133+. Hematopoietic engraftment with >1.0 × 109/l neutrophils and >50 × 109/l platelets was reached within 13 and 24 days, respectively. At a follow-up of 11½ months after autologous transplantation, the patient is in complete remission. To our knowledge, the successful transplantation with a CD133 selected graft is the first one to be reported worldwide. CD133 selected cells may serve as an alternative in the case of CD34+ malignancy.

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Acknowledgements

This project was supported by ‘Hilfe für Krebskranke Kinder Frankfurt eV’, by ‘Frankfurter Stiftung für Krebskranke Kinder’ and by ‘Paul und Ursula Klein-Stiftung’. We acknowledge the excellent technical support of Andrea Brinkmann, Ilse Bühler and Stephanie Grohal.

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Authors and Affiliations

  1. Department of Pediatric Hematology and Oncology, University Hospital Frankfurt, Frankfurt, Germany

    U Koehl, S Zimmermann, R Esser, J Sörensen, HP Grüttner, T Klingebiel & D Schwabe

  2. Institute for Transfusion Medicine and Immunohematology, RCBDS Hessia, Frankfurt, Germany

    M Duchscherer & E Seifried

Authors
  1. U Koehl
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  2. S Zimmermann
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  3. R Esser
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  4. J Sörensen
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  5. HP Grüttner
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  6. M Duchscherer
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  7. E Seifried
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  8. T Klingebiel
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  9. D Schwabe
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Koehl, U., Zimmermann, S., Esser, R. et al. Autologous transplantation of CD133 selected hematopoietic progenitor cells in a pediatric patient with relapsed leukemia. Bone Marrow Transplant 29, 927–930 (2002). https://doi.org/10.1038/sj.bmt.1703558

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  • DOI: https://doi.org/10.1038/sj.bmt.1703558

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