Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Autografting

Autologous hematopoietic cell transplantation for non-Hodgkin's lymphoma: 100 month follow-up

Bone Marrow Transplantation volume 29, pages 673–679 (2002)Cite this article

Abstract

One hundred and ten adult patients with non-Hodgkin's lymphoma (NHL) received an autologous hematopoietic cell transplant (ABMT) from 1988 to 1993. All received a uniform preparative regimen of cyclophosphamide, BCNU and etoposide (CBV). Twenty-one percent had low grade histologies, 54% intermediate grade, and 25% high grade. Median follow-up of 48 survivors is 100 months. Kaplan–Meier 10 year overall survival and relapse-free survival for the entire group is 42% and 32%, respectively. Fifty patients were in complete remission 2 years post transplant. With additional follow-up, patients with high grade malignancies are cured, while patients with intermediate or low grade histologies were at continued risk of relapse up to 5 years post transplant. Of 39 patients in complete remission 5 years post transplant, none have relapsed with additional extended follow-up. We conclude that patients with NHL treated with ABMT, if in CR 5 years post transplant, are at very low risk of relapse with extended follow-up, suggesting the possibility of cure for all histologies, including those with low grade NHL.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6

Similar content being viewed by others

References

  1. Philip T, Guglielmi C, Hagenbeek A et al. Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma New Engl J Med 1995 333: 1540 1545

    Article  CAS  Google Scholar 

  2. Vose J, Zhang MJ, Rowlings P et al. Autologous transplantation for diffuse aggressive non-Hodgkin's lymphoma in patients achieving remission: a report from the Autologous Blood and Marrow Registry J Clin Oncol 2001 19: 406 413

    Article  CAS  Google Scholar 

  3. Copelan EA, Penza SL, Pohlman B et al. Autotransplantation following busulfan, etoposide and cyclophosphamide in patients with non-Hodgkin's lymphoma Bone Marrow Transplant 2000 25: 1243 1248

    Article  CAS  Google Scholar 

  4. Haioun C, Lepage E, Gisselbrecht C et al. Survival benefit of high-dose chemotherapy in poor risk aggressive non-Hodgkin's lymphoma: final analysis of the prospective LNH87–2 Protocol – a groupe d'etude des lymphomes de l'adulte study J Clin Oncol 2000 18: 3025 3030

    Article  CAS  Google Scholar 

  5. Wheeler C, Strawderman M, Ayash L et al. Prognostic factors for treatment outcome in autotransplantation of intermediate grade with high grade non-Hodgkin's lymphoma with cyclophosphamide, carmustine, and etoposide J Clin Oncol 1993 11: 1085 1091

    Article  CAS  Google Scholar 

  6. Philip T, Armitage J, Spitzer G et al. High-dose therapy and autologous bone marrow transplantation after failure of chemotherapy in adults with intermediate grade or high grade non-Hodgkin's lymphoma New Engl J Med 1987 316: 1493 1498

    Article  CAS  Google Scholar 

  7. Mills W, Chopra R, McMillan A et al. BEAM chemotherapy and autologous bone marrow transplantation for patients with relapsed or refractory non-Hodgkin's lymphoma J Clin Oncol 1995 13: 588 595

    Article  CAS  Google Scholar 

  8. Cervantes F, Shu XO, McGlave PB et al. Autologous bone marrow transplantation for non-transformed low-grade non-Hodgkin's lymphoma Bone Marrow Transplant 1995 16: 387 392

    CAS  PubMed  Google Scholar 

  9. Foran JM, Apostilidis J, Papamichael D et al. High-dose therapy with autologous hematopoietic support in patients with transformed follicular lymphoma: a study of 27 patients from a single centre Ann Oncol 1998 9: 865 869

    Article  CAS  Google Scholar 

  10. Vose J, Bierman P, Lynch J et al. Effect of follicularity on autologous transplantation for large cell non-Hodgkin's lymphoma J Clin Oncol 1998 16: 844 849

    Article  CAS  Google Scholar 

  11. Voso MT, Martin S, Hohaus S et al. Prognostic factors for the clinical outcome of patients with follicular lymphoma following high-dose therapy and peripheral blood stem cell transplantation (PBSCT) Bone Marrow Transplant 2000 25: 957 964

    Article  CAS  Google Scholar 

  12. Bierman P, Vose J, Anderson B . High dose chemotherapy with autologous hematopoietic rescue for follicular low grade non-Hodgkin's lymphoma J Clin Oncol 1997 15: 445 450

    Article  CAS  Google Scholar 

  13. Bastion Y, Brice P, Haioun C et al. Intensive therapy with peripheral blood progenitor cell transplantation in 60 patients with poor prognosis follicular lymphoma Blood 1995 86: 3257 3262

    CAS  Google Scholar 

  14. Haas R, Moos M, Mohle R et al. High-dose therapy with peripheral blood progenitor cell transplantation in low grade non-Hodgkin's lymphoma Bone Marrow Transplant 1996 17: 149 155

    CAS  Google Scholar 

  15. Bolwell B, Goormastic M, Andresen S . Durability of remission after ABMT for NHL: the importance of the 2-year evaluation point Bone Marrow Transplant 1997 19: 443 448

    Article  CAS  Google Scholar 

  16. Rosenberg S, Berard C, Brown B et al. National Cancer Institute Sponsored Study of Classifications of Non-Hodgkin's Lymphoma's, Summary and Description of a Working Formulation for Clinical Usage. The Non-Hodgkin's Lymphoma Pathologic Classification Project Cancer 1982 49: 2112 2135

    Article  Google Scholar 

  17. Shipp MA, Harrington DP, Anderson JR et al. The International Non-Hodgkin's Lymphoma Prognostic Factors Project. A predictive model for aggressive non-Hodgkin's lymphoma New Engl J Med 1993 329: 987 994

    Article  Google Scholar 

  18. Weisdorf D, Andersen J, Glick J et al. Survival after relapse of low grade non-Hodgkin's lymphoma: implications for marrow transplantation J Clin Oncol 1992 10: 942 947

    Article  CAS  Google Scholar 

  19. Bastion Y, Sebban C, Berger F et al. Incidence, predictive factors, and outcome of lymphoma transformation in follicular lymphoma patients J Clin Oncol 1997 15: 1587 1594

    Article  CAS  Google Scholar 

  20. Gallagher CJ, Gregory WM, Jones AE et al. Follicular lymphoma: prognostic factors for response and survival J Clin Oncol 1986 4: 1470 1480

    Article  CAS  Google Scholar 

  21. Paryani S, Hoppe R, Cox R et al. Analysis of non-Hodgkin's lymphomas with nodular and favorable histologies, stages I and II Cancer 1983 52: 2300 2307

    Article  CAS  Google Scholar 

  22. Lawrence T, Urba W, Steinberg S et al. Retrospective analysis of stage I and stage II indolent lymphomas at the National Cancer Institute J Radiat Oncol Biol Phys 1988 14: 417 424

    Article  CAS  Google Scholar 

  23. Vaughan Hudson B, Vaughan Hudson G, MacLennan KA et al. Clinical stage I non-Hodgkin's lymphoma: long-term follow-up of patients treated by the British National Lymphoma Investigation with radiotherapy alone as initial therapy Br J Cancer 1994 69: 1088 1093

    Article  CAS  Google Scholar 

  24. MacManus M, Hoppe R . Is radiotherapy curative for stage I and II low-grade follicular lymphoma? Results of a long-term follow-up study of patients treated at Stanford University J Clin Oncol 1996 14: 1282 1290

    Article  CAS  Google Scholar 

  25. Apostilidis J, Gupta R, Grnezelias D et al. High-dose chemotherapy with autologous bone marrow support as consolidation of remission in follicular lymphoma: long-term clinical and molecular follow-up J Clin Oncol 2000 18: 527 536

    Article  Google Scholar 

  26. Freedman A, Neuberg D, Mauch P et al. Long-term follow-up of autologous bone marrow transplantation in patients with relapsed follicular lymphoma Blood 1999 94: 3325 3333

    CAS  Google Scholar 

  27. Horning S, Negrin R, Hoppe R et al. High-dose therapy and autologous bone marrow transplantation for follicular lymphoma in first complete or partial remission: results of a phase II clinical trial Blood 2001 97: 404 409

    Article  CAS  Google Scholar 

  28. Micaleff I, Lillington D, Apostilidis J et al. Therapy related myelodysplasia and secondary acute myelogenous leukemia after high-dose therapy with autologous hematopoietic progenitor cell support for lymphoid malignancies J Clin Oncol 2000 18: 947 955

    Article  Google Scholar 

  29. Milligan D, Ruiz de Elvira M, Kolb HJ et al. Secondary leukaemia and myelodysplasia after autografting for lymphoma: results from the EBMT Br J Haematol 1999 106: 1020 1026

    Article  CAS  Google Scholar 

  30. Armitage J . Editorial: myelodysplasia and acute leukemia after autologous bone marrow transplantation J Clin Oncol 2000 18: 945 946

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Hematology and Medical Oncology, Taussig Cancer Center, and Transplant Center, The Cleveland Clinic Foundation, Cleveland, OH, USA

    B Bolwell, M Kalaycio, R Sobecks, S Andresen, M Mcbee, L Kuczkowski, L Rybicki & B Pohlman

Authors
  1. B Bolwell
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M Kalaycio
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R Sobecks
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S Andresen
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M Mcbee
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. L Kuczkowski
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. L Rybicki
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. B Pohlman
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bolwell, B., Kalaycio, M., Sobecks, R. et al. Autologous hematopoietic cell transplantation for non-Hodgkin's lymphoma: 100 month follow-up. Bone Marrow Transplant 29, 673–679 (2002). https://doi.org/10.1038/sj.bmt.1703525

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1703525

Keywords

This article is cited by

Search

Advanced search

Quick links