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Allogeneic BMT for infantile acute leukemia: what is the optimal conditioning regimen?

Bone Marrow Transplantation volume 29, pages 630–631 (2002)Cite this article

Leung et al1 recently reported their results in 22 infants with acute leukemia or myelodysplasia who underwent allogeneic BMT. Patients received a radiation-containing regimen prior to BMT. The authors report a 5-year event-free survival of 45.5%.

Total body irradiation had been recognized to be associated with adverse effects on the growth and endrocrinologic status of BMT recipients. In a study concerning late effects of treatment in survivors of childhood AML, Leung et al2 reported that younger age (at the time of diagnosis or initiation of radiation therapy) was a risk factor for development of academic difficulties and greater decrease in height. Furthermore, they concluded that those who received TBI and allogeneic BMT had an increased risk for development of growth hormone deficiency, hypothyroidism, hypogonadism, infertility and cataracts. Similarly, Cohen et al3 concluded in their study of final height of patients who had undergone BMT during childhood that irradiation was one of the major factors for long-term height loss.

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Authors and Affiliations

  1. Department of Pediatric Hematology Oncology MBC 53, King Faisal Specialist Hospital, PO Box 3354, Riyadh, Saudi Arabia

    M Ayas, A Belgaumi, M Al-Mahr, A Al-Jefri & H Solh

  2. St Jude Children's Research Hospital, 332 N Lauderdale Street, Memphis, TN 38105, USA

    W Leung

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  1. M Ayas
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  2. A Belgaumi
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  3. M Al-Mahr
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  4. A Al-Jefri
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  6. W Leung
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Ayas, M., Belgaumi, A., Al-Mahr, M. et al. Allogeneic BMT for infantile acute leukemia: what is the optimal conditioning regimen?. Bone Marrow Transplant 29, 630–631 (2002). https://doi.org/10.1038/sj.bmt.1703420

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