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Dental development after successful treatment of infantile osteopetrosis with bone marrow transplantation

Bone Marrow Transplantation volume 29, pages 537–540 (2002)Cite this article

Abstract

A 3-week-old boy was diagnosed with congenital osteopetrosis. He underwent a bone marrow transplant at 6 weeks of age. At 3 years of age the primary teeth had all erupted, but the canines and the first molars totally lacked root development. The teeth were smaller in size and had evidence of both enamel hypomineralization and hypoplasia. In the permanent dentition, multiple missing teeth were found. The incisors were conical and the mandibular laterals were extremely small. All permanent teeth had normal eruption. This case shows that dental development and eruption of teeth can be reconstituted in a child with congenital osteopetrosis. Bone marrow transplantation induces normalization of osteoclast function, which is a prerequisite for normal dental development and eruption of teeth.

Bone Marrow Transplantation (2002) 29, 537–540. doi:10.1038/sj.bmt.1703416

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Acknowledgements

This study was supported by a grant from the Swedish Children's Cancer Society.

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Authors and Affiliations

  1. Specialist Pediatric Dentistry Clinic, Mölndal, University of Göteborg, Göteborg, Sweden

    B Jälevik

  2. Department of Pediatrics, University of Göteborg, Göteborg, Sweden

    A Fasth

  3. Department of Pediatric Dentistry, Karolinska Institutet, Stockholm, Sweden

    G Dahllöf

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  1. B Jälevik
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  2. A Fasth
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  3. G Dahllöf
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Jälevik, B., Fasth, A. & Dahllöf, G. Dental development after successful treatment of infantile osteopetrosis with bone marrow transplantation. Bone Marrow Transplant 29, 537–540 (2002). https://doi.org/10.1038/sj.bmt.1703416

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