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Stem Cell Source

Arylsulfatase-A in umbilical cord blood: gestational age and mode of delivery do not influence enzyme activity

Bone Marrow Transplantation volume 29, pages 487–490 (2002)Cite this article

Abstract

The possibility of using umbilical cord blood for transplantation in several enzyme deficiencies has received increasing attention because of the availability of cord blood, the reduced incidence of post-transplantation complications, such as graft-versus-host disease and the possible accomplishment of good corrective results following transplantation, even in cases of greater HLA disparity. The use of hematopoietic stem cells from unrelated donors is even more highly recommended for the treatment of inherited enzyme deficiencies, because it might reduce the risk of the transplanted cells originating from a carrier of the defect, which might have an inadequate corrective ability. Our study was designed to elucidate whether the gestational age and mode of delivery influences the arylsulfatase-A activity in the umbilical cord blood. Enzyme activities proved to be similar in the four populations studied (full-term normal spontaneous vaginal delivery, full-term caesarean section, preterm normal spontaneous vaginal delivery and preterm caesarean section). Therefore, umbilical cord blood samples seem to be suitable for transplantation in metachromatic leukodystrophy, regardless of gestational age and mode of delivery. Moreover, our results are the first published data on normal values for arylsulfatase-A activity in human umbilical cord blood.

Bone Marrow Transplantation (2002) 29, 487–490. doi:10.1038/sj.bmt.1703405

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Authors and Affiliations

  1. Mullikin Medical Centers, Artesia, CA, USA

    GD Georgeson

  2. Department of Pathophysiology, University of Szeged, Szeged, Hungary

    BJ Szöny

  3. Department of Obstetrics and Gynecology, WHO Collaborating Center for Research in Human Reproduction, University of Szeged, Szeged, Hungary

    L Kovács

  4. Department of Pediatrics, University of Szeged, Szeged, Hungary

    K Streitman, E Sallay & A László

  5. Blood Transfusion Center, University of Szeged, Hungary

    A Kovács

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  1. GD Georgeson
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  2. BJ Szöny
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  4. E Sallay
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  5. A Kovács
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  6. L Kovács
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  7. A László
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Georgeson, G., Szöny, B., Streitman, K. et al. Arylsulfatase-A in umbilical cord blood: gestational age and mode of delivery do not influence enzyme activity. Bone Marrow Transplant 29, 487–490 (2002). https://doi.org/10.1038/sj.bmt.1703405

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