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Allogeneic blood stem cell transplantation following non-myeloablative conditioning for hypereosinophilic syndrome

Bone Marrow Transplantation volume 29, pages 457–458 (2002)Cite this article

Abstract

A male patient with hypereosinophilic syndrome (HES) underwent an allogeneic blood stem cell transplantation from a female donor following non-myeloablative conditioning consisting of a 2 Gy dose of TBI and fludarabine 30 mg/m2 intravenously on three days. Before transplantation 100% of the mitotic bone marrow cells of the patient showed a clonal karyotype abnormality. Three months after the transplantation eosinophilia had resolved and a chromosome analysis revealed normal female karyotype. The present study shows that stem cell transplantation after non-myeloablative conditioning may have curative potential for HES.

Bone Marrow Transplantation (2002) 29, 457–458. doi:10.1038/sj.bmt.1703379

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Authors and Affiliations

  1. Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland

    E Juvonen, L Volin & T Ruutu

  2. South-Carelia Central Hospital, Lappeenranta, Finland

    A Koponen

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  1. E Juvonen
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  2. L Volin
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  3. A Koponen
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  4. T Ruutu
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Juvonen, E., Volin, L., Koponen, A. et al. Allogeneic blood stem cell transplantation following non-myeloablative conditioning for hypereosinophilic syndrome. Bone Marrow Transplant 29, 457–458 (2002). https://doi.org/10.1038/sj.bmt.1703379

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  • DOI: https://doi.org/10.1038/sj.bmt.1703379

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