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Post-Transplant Complications

Glucose-6-phosphate dehydrogenase deficiency and hematopoietic stem cell transplantation

Bone Marrow Transplantation volume 29, pages 399–402 (2002)Cite this article

Abstract

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked hemolytic enzymopathy affecting 3% of Southern Chinese males. Among 275 adult allogeneic hematopoietic stem cell transplantations (SCT), five cases (1.8%) each of donors and recipients were G6PD deficient. Among 107 autologous SCT, four patients (3.7%) were G6PD deficient. All subjects were male, except for two female patients with chronic myeloid leukemia (CML). The incidence of G6PD deficiency in female CML patients was significantly higher than the background female incidence (P = 0.004), but comparable with that in the males (P = 0.664). There was no significant hemolysis or delay in red cell engraftment, and all but one patient converted to donor G6PD screening status. One female patient achieved partial correction of her G6PD status and relapsed at 10 months. We suggest that G6PD deficiency should be tested for in all marrow donors and recipients in susceptible populations. From our data, there is a suggestion of increased clinical incidence of G6PD deficiency in female patients with multi-lineage clonal marrow disorders.

Bone Marrow Transplantation (2002) 29, 399–402. doi:10.1038/sj.bmt.1703369

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References

  1. Lee AC, Lau YL, Chan CF et al. Bone marrow transplantation for thalassemia in Hong Kong: the early experience Bone Marrow Transplant 1993 12 (Suppl. 1): 49 50

    Google Scholar 

  2. Tanphaichitr VS, Suvatte V, Issaragrisil S et al. Successful bone marrow transplantation in a child with red blood cell pyruvate kinase deficiency Bone Marrow Transplant 2000 26: 689 690

    Article  CAS  Google Scholar 

  3. Lo KK, Chan ML, Lo IFM et al. Neonatal screening for glucose-6-phosphate dehydrogenase deficiency in Hong Kong In: Lam STS, Pang CCD (eds) Neonatal and Perinatal Screening, the Asian Pacific Perspective The Chinese University Press: Hong Kong 1996 pp 33 35

    Google Scholar 

  4. Fok TF, Lau SP, Fung KP . Cord blood G-6-PD activity by quantitative enzyme assay and fluorescent spot test in Chinese neonates Aust Paediatr J 1985 21: 23 25

    CAS  PubMed  Google Scholar 

  5. Kwong YL, Chiu EK, Liang RH et al. Essential thrombocythemia with BCR/ABL rearrangement Cancer Genet Cytogenet 1996 89: 74 76

    Article  CAS  Google Scholar 

  6. Au WY, Chan AC, Lie AK et al. Isolated extramedullary relapse after allogeneic bone marrow transplantation for chronic myeloid leukemia Bone Marrow Transplant 1998 22: 99 102

    Article  CAS  Google Scholar 

  7. Au WY, Lie AK, Ma SK et al. Therapy-related myelodysplastic syndrome of recipient origin after allogeneic bone marrow transplantation for acute lymphoblastic leukaemia Br J Haematol 2001 112: 424 426

    Article  CAS  Google Scholar 

  8. Chan TK, Todd D . Characteristics and distribution of glucose-6-phosphate dehydrogenase-deficient variants in South China Am J Hum Genet 1972 24: 475 484

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Lam VM, Huang W, Lam ST et al. Rapid detection of common Chinese glucose-6-phosphate dehydrogenase (G6PD) mutations by denaturing gradient gel electrophoresis (DGGE) Genet Anal 1996 12: 201 206

    Article  CAS  Google Scholar 

  10. Suzuki H, Asano H, Ohashi H et al. Clonality analysis of refractory anemia with ring sideroblasts: simultaneous study of clonality and cytochemistry of bone marrow progenitors Leukemia 1999 13: 130 134

    Article  CAS  Google Scholar 

  11. Li KC, Lai SS, Lam ST . Adequacy and pitfalls of G6PD deficiency counseling in Hong Kong Southeast Asian J Trop Med Public Health 1999 30 (Suppl. 2): 79 83

    Google Scholar 

  12. Yam PY, Petz LD, Knowlton RG et al. Use of DNA restriction fragment length polymorphisms to document marrow engraftment and mixed hematopoietic chimerism following bone marrow transplantation Transplantation 1987 43: 399 407

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors would like to thank N Cheng for data management and E Chan for technical assistance. This study was supported by the Kadoorie Charitable Foundation.

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Authors and Affiliations

  1. Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong

    WY Au, AKW Lie, R Liang, T Cheng & YL Kwong

  2. Department of Pathology, University of Hong Kong, Queen Mary Hospital, Hong Kong

    SK Ma

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  1. WY Au
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  2. SK Ma
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  3. AKW Lie
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  4. R Liang
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  5. T Cheng
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  6. YL Kwong
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Au, W., Ma, S., Lie, A. et al. Glucose-6-phosphate dehydrogenase deficiency and hematopoietic stem cell transplantation. Bone Marrow Transplant 29, 399–402 (2002). https://doi.org/10.1038/sj.bmt.1703369

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