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Conditioning with high-dose cyclophosphamide may not be sufficient to provide a long-term remission of paroxysmal nocturnal hemoglobinuria following syngeneic peripheral blood stem cell transplantation

Bone Marrow Transplantation volume 28, pages 987–988 (2001)Cite this article

Abstract

A patient with paroxysmal nocturnal hemoglobinuria (PNH) received a syngeneic peripheral blood stem cell transplant (PBSCT) with high-dose cyclophosphamide (CY) conditioning. He had a reasonable engraftment and complete hematologic recovery. However, at 12 months after PBSCT, he became symptomatic and peripheral blood cells were almost entirely composed of glycosylphosphatidylinositol-anchored proteins deficient cells. This case suggests that high-dose CY may not exert a significant effect on PNH clones in the long term, although it had been effective in allogeneic BMT. In view of the possible autoimmune basis, it seems to be necessary to include other immunosuppressive therapy including ALG in addition to CY. Bone Marrow Transplantation (2001) 28, 987–988.

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Authors and Affiliations

  1. Catholic Hematopoietic Stem Cell Transplantation Center, College of Medicine, The Catholic University of Korea, Seoul, Korea

    SG Cho, HS Eom, CY Jin, CW Han & CC Kim

  2. Department of Clinical Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea

    J Lim & Y Kim

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  1. SG Cho
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  2. J Lim
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Cho, S., Lim, J., Kim, Y. et al. Conditioning with high-dose cyclophosphamide may not be sufficient to provide a long-term remission of paroxysmal nocturnal hemoglobinuria following syngeneic peripheral blood stem cell transplantation. Bone Marrow Transplant 28, 987–988 (2001). https://doi.org/10.1038/sj.bmt.1703259

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