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Platelet glycoprotein complex Ia/IIa antibodies cause neonatal alloimmune thrombocytopenia but do not inhibit megakaryopoiesis and platelet recovery after allogeneic cord blood stem cell transplantation

Bone Marrow Transplantation volume 28, pages 803–806 (2001)Cite this article

Abstract

A sibling cord blood (CB) transplantation was performed in a boy with Wiskott–Aldrich syndrome. The CB (31 × 106 CD34+ cells) derived from a newborn sister with neonatal alloimmune thrombocytopenia (NAIT) with 40000 platelets/μl, caused by a maternal anti-HPA-5b and HLA-A2 antibody. Maternal serum did not inhibit clonogenicity after in vitro testing of megakaryopoiesis. Accordingly, this CB was accepted for sibling transplantation. The transplantation showed a good course with fast and sustained hematopoietic reconstitution (granulocytes >500/μl on day +16, platelets >50 000/μl on day +30). This case demonstrates a successful CB transplantation from a donor suffering from NAIT. Bone Marrow Transplantation (2001) 28, 803–806.

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Acknowledgements

We thank Marion Behr, Anja Pohlmeyer and Astrid Kraemer for excellent technical assistance.

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Authors and Affiliations

  1. Department of Transfusion Medicine/Transplantation Immunology, University Hospital Muenster, Muenster, Germany

    U Cassens, H Garritsen, R Kelsch & W Sibrowski

  2. Department of Pediatrics, University Hospital Muenster, Muenster, Germany

    N van der Werf & M Frosch

  3. Department of Obstetrics and Gynecology, University Hospital Muenster, Muenster, Germany

    R Witteler

  4. Department of Pediatrics, Charité, Humboldt-University Berlin, Berlin, Germany

    W Ebell

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  1. U Cassens
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  2. H Garritsen
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Cassens, U., Garritsen, H., Kelsch, R. et al. Platelet glycoprotein complex Ia/IIa antibodies cause neonatal alloimmune thrombocytopenia but do not inhibit megakaryopoiesis and platelet recovery after allogeneic cord blood stem cell transplantation. Bone Marrow Transplant 28, 803–806 (2001). https://doi.org/10.1038/sj.bmt.1703235

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  • DOI: https://doi.org/10.1038/sj.bmt.1703235

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