Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Case Report
  • Published:

Remission of severe, intractable autoimmune haemolytic anaemia following matched unrelated donor transplantation

Abstract

Immune-mediated haemolytic anaemia presenting post allogeneic bone marrow transplantation is often alloimmune in origin due to ABO or minor red cell incompatibilities. Autoimmune haemolytic anaemia is also recognised, is frequently difficult to treat and overall prognosis is often poor, usually from associated problems. Here, we present a case report of autoimmune haemolysis presenting in an 8-year-old boy 6 months post allogeneic bone marrow transplant requiring 4 years of immunosuppressive therapy before remission of haemolysis. This case report highlights the fact that it is possible for haemolysis to resolve post transplant even after years of immunosuppressive therapy. Bone Marrow Transplantation (2001) 28, 791–793.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Purchase on Springer Link

Instant access to full article PDF

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Hows J, Beddow K, Gordon-Smith E et al. Donor-derived red blood cell antibodies and immune haemolysis after allogeneic bone marrow transplantation Blood 1986 67: 177–181

    CAS  PubMed  Google Scholar 

  2. Klumpp TR, Caligiuri MA, Rabinowe SN et al. Autoimmune pancytopenia following allogeneic bone marrow transplantation Bone Marrow Transplant 1990 6: 445–447

    CAS  PubMed  Google Scholar 

  3. Bierling P, Cordonnier C, Fromont P . Acquired autoimmune thrombocytopenia after allogeneic bone marrow transplantation Br J Haematol 1985 59: 643–646

    Article  CAS  Google Scholar 

  4. Bashey A, Owen I, Lucas GF et al. Late onset immune pancytopenia following bone marrow transplantation Br J Haematol 1991 78: 268–274

    Article  CAS  Google Scholar 

  5. Chen FE, Owen I, Savage D et al. Late onset haemolysis and red cell autoimmunisation after allogeneic bone marrow transplant Bone Marrow Transplant 1997 19: 491–495

    Article  CAS  Google Scholar 

  6. Drobyski WR, Potluri J, Sauer D, Gottschall JL . Autoimmune hemolytic anaemia following T cell depleted allogeneic bone marrow transplantation Bone Marrow Transplant 1996 17: 1093–1099

    CAS  PubMed  Google Scholar 

  7. Foerster J . Autoimmune haemolytic anemia. In: Lee G, Bithell T, Foerster J (eds) Clinical Hematology Lea & Febiger: Philadelphia 1993 1170–1196

    Google Scholar 

  8. Eden OB, Harrison G, Richards S et al. Long-term follow up of the United Kingdom Medical Research Council protocols for childhood acute lymphoblastic leukaemia, 1980–1997. Medical Research Council Childhood Leukaemia Working Party Leukemia 2000 14: 2307–2320

    Article  CAS  Google Scholar 

  9. Frankel S, Cunningham I, Reich L . Autoimmune haemolytic anaemia following bone marrow transplantation for chronic myelogenous leukaemia Blood 1989 74: 226a

    Google Scholar 

  10. Godder K, Pati AR, Abhyankar SH et al. De novo chronic graft-versus-host disease presenting as haemolytic anaemia following partially mismatched related donor bone marrow transplant Bone Marrow Transplant 1997 19: 813–817

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pratt, G., Kinsey, S. Remission of severe, intractable autoimmune haemolytic anaemia following matched unrelated donor transplantation. Bone Marrow Transplant 28, 791–793 (2001). https://doi.org/10.1038/sj.bmt.1703232

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1703232

Keywords

This article is cited by

Search

Quick links