Abstract
We report a 62-year-old male who underwent non-myeloablative allogeneic peripheral blood stem cell transplantation (PBSCT) because of his life-threatening severe pancytopenia due to refractory Waldenström's macroglobulinemia. This therapy was performed safely and he made a marked recovery from his cytopenia that had not been improved with any other therapy. Bone marrow aspirates showed post-transplant mixed chimerism during engraftment, and became completely donor-derived after a series of GVHD symptoms, without subsequent donor lymphocyte infusion. Our results suggest that non-myeloablative allogeneic PBSCT could be a good alternative for patients suffering from multi-drug resistant Waldenström's macroglobulinemia. Bone Marrow Transplantation (2001) 28, 609–611.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Desikan R, Dhodapkar M, Siegel D et al. High-dose therapy with autologous haemopoietic stem cell support for Waldenström's Macroglobulinemia Br J Haematol 1999 105: 993–996
Dreger P, Glass B, Kuse R et al. Myeloablative radiochemotherapy followed by reinfusion of purged autologous stem cells for Waldenström's macroglobulinaemia Br J Haematol 1999 106: 115–118
Yang L, Wen BP, Li HM et al. Autologous peripheral blood stem cell transplantation for Waldenström's macroglobulinemia Bone Marrow Transplant 1999 24: 929–930
Martino R, Shah A, Romero P et al. Allogeneic bone marrow transplantation for advanced Waldenström's macroglobulinemia Bone Marrow Transplant 1999 23: 747–749
Carella AM, Champlin R, Slavin S et al. Mini-allografts: ongoing trials in humans Bone Marrow Transplant 2000 25: 345–350
Khouri IF, Keating M, Körbling M et al. Transplant-lite: induction of graft-versus-malignancy using fludarabine-based nonablative chemotherapy and allogeneic blood progenitor-cell transplantation as treatment for lymphoid malignancies J Clin Oncol 1998 16: 2817–2824
Giralt S, Weber D, Aleman A et al. Non myeloablative conditioning with fludarabine/melphalan (FM) for patients with multiple myeloma (MM) Blood 1999 94: (Suppl. 1) 347a (Abst.1549)
Dimopoulos MA, Panayiotidis P, Moulopoulos LA et al. Waldenström's macroglobulinemia: clinical features, complications, and management J Clin Oncol 2000 18: 214–226
Acknowledgements
We would like to thank Masaharu Kouno, Toshitsugu Negoro and Takahiro Yonemoto for their skillful technical assistance.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ueda, T., Hatanaka, K., Kosugi, S. et al. Successful non-myeloablative allogeneic peripheral blood stem cell transplantation (PBSCT) for Waldenström's macroglobulinemia with severe pancytopenia. Bone Marrow Transplant 28, 609–611 (2001). https://doi.org/10.1038/sj.bmt.1703190
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1703190
Keywords
This article is cited by
-
Stem cell transplant for Waldenström macroglobulinemia: an underutilized technique
Bone Marrow Transplantation (2012)
-
Long-term graft-versus-Waldenström macroglobulinemia effect following reduced intensity conditioning allogeneic stem cell transplantation
Bone Marrow Transplantation (2007)
-
Evidence of graft-versus-Waldenstrom's macroglobulinaemia effect after allogeneic stem cell transplantation: a single centre experience
Bone Marrow Transplantation (2007)
-
Stem cell transplantation (SCT) for Waldenstrom's macroglobulinemia (WM)
Bone Marrow Transplantation (2002)