Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Case Report
  • Published:

CMV reactivation induced BK virus-associated late onset hemorrhagic cystitis after peripheral blood stem cell transplantation

Bone Marrow Transplantation volume 28, pages 613–614 (2001)Cite this article

Abstract

Hemorrhagic cystitis (HC) is a known complication of stem cell transplantation. In contrast to early-onset HC that is usually attributed to cyclophosphamide and occurs within a few days of infusion, late onset HC is associated with viral infection. In recent years BK virus has emerged as an important causative agent. We describe two patients who developed late onset HC (38 and 92 days post transplant) associated with BK viruria concomitant with CMV reactivation and suggest a possible role of CMV in the process of BK virus DNA replication. Bone Marrow Transplantation (2001) 28, 613–614.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Arthur RR, Shah KV, Baust SJ et al. Association of BK viruria with hemorrhagic cystitis in recipients of bone marrow transplants New Engl J Med 1986 315: 230–234

    Article  CAS  Google Scholar 

  2. Russel SJ, Vowels MR, Vale T . Haemorrhagic cystitis in paediatric bone marrow transplant patients: an association with infective agents, GVHD and prior cyclophosphamide Bone Marrow Transplant 1994 13: 533–539

    Google Scholar 

  3. Azzi A, Fanci R, Bosi A et al. Monitoring of polyomavirus BK viruria in bone marrow transplantation patients by DNA hybridization assay and by polymerase chain reaction: an approach to assess the relationship between BK viruria and hemorrhagic cystiti Bone Marrow Transplant 1994 14: 235–240

    CAS  Google Scholar 

  4. Bedi A, Miller CB, Hanson JL et al. Association of BK virus with failure of prophylaxis against hemorrhagic cystitis following bone marrow transplantation J Clin Oncol 1995 13: 1103–1109

    Article  CAS  Google Scholar 

  5. Vianelli N, Renga M, Azzi A et al. Sequential vidarabine infusion in the treatment of polyoma virus-associated acute haemorrhagic cystitis late after allogeneic bone marrow transplantation Bone Marrow Transplant 2000 25: 319–320

    Article  CAS  Google Scholar 

  6. Spach DH, Bauwens JE, Myerson D et al. Cytomegalovirus-induced hemorrhagic cystitis following bone marrow transplantation Clin Infect Dis 1993 16: 142–144

    Article  CAS  Google Scholar 

  7. Childs R, Sanchez C, Engler H et al. High incidence of adeno- and polyomavirus-induced hemorrhagic cystitis in bone marrow allotransplantation for hematological malignancy following T cell depletion and cyclosporine Bone Marrow Transplant 1998 22: 889–893

    Article  CAS  Google Scholar 

  8. Held TK, Biel SS, Nitsche A et al. Treatment of BK virus-associated hemorrhagic cystitis and simultaneous CMV reactivation with cidofovir Bone Marrow Transplant 2000 26: 347–350

    Article  CAS  Google Scholar 

  9. Heilbronn R, Albrecht I, Stephan S et al. Human cytomegalovirus induces JC virus DNA replication in human fibroblasts Proc Natl Acad Sci USA 1993 90: 11406–11410

    Article  CAS  Google Scholar 

  10. Bielorai B, Toren A, Wolach B et al. Successful treatment of invasive aspergillosis in chronic granulomatous disease by granulocyte transfusions followed by peripheral blood stem cell transplantation Bone Marrow Transplant 2000 26: 1025–1028

    Article  CAS  Google Scholar 

  11. Nickeleit V, Klimkait T, Binet IF et al. Testing for polyomavirus type BK DNA in plasma to identify renal-allograft recipients with viral nephropathy New Engl J Med 2000 342: 1309–1315

    Article  CAS  Google Scholar 

  12. Schlehofer JR, Gissmann L, Matz B, Zur Hausen H . Herpes simplex virus-induced amplification of SV40 sequences in transformed Chinese hamster embryo cells Int J Cancer 1983 3: 99–103

    Article  Google Scholar 

  13. Pari GS, St Jeor SC . Human cytomegalovirus major immediate–early gene product can induce SV40 DNA replication in human embryonic lung cells Virology 1990 179: 758–794

    Google Scholar 

  14. Seber A, Shu XO, Defor T et al. Risk factors for severe hemorrhagic cystitis following BMT Bone Marrow Transplant 1999 23: 35–40

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatric Hematology/Oncology, The Sheba Medical Center, Tel-Hashomer and Sackler School of Medicine, Tel-Aviv University, Israel

    B Bielorai, G Rechavi & A Toren

  2. Laboratory of Virology, The Sheba Medical Center, Tel-Hashomer and Sackler School of Medicine, Tel-Aviv University, Israel

    LM Shulman

Authors
  1. B Bielorai
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. LM Shulman
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G Rechavi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A Toren
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bielorai, B., Shulman, L., Rechavi, G. et al. CMV reactivation induced BK virus-associated late onset hemorrhagic cystitis after peripheral blood stem cell transplantation. Bone Marrow Transplant 28, 613–614 (2001). https://doi.org/10.1038/sj.bmt.1703187

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1703187

Keywords

This article is cited by

Search

Advanced search

Quick links