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Parental Donor Transplants

Superior survival of blood and marrow stem cell recipients given maternal grafts over recipients given paternal grafts

Bone Marrow Transplantation volume 28, pages 375–380 (2001)Cite this article

Abstract

During the reproductive period, mothers and offspring exchange hematopoietic cells and develop a form of immunological tolerance bidirectionally. To examine whether previous experience of such communication has any remote effect when maternal hematopoietic cells are later transplanted to the children, we retrospectively compared the outcomes of blood and marrow stem cell transplantation from maternal donors (n = 46) to those from paternal donors (n = 50) by using the database of the Japanese nationwide surveys for adult hematopoietic cell transplants between 1990 and 1998. At 5 years, recipients of maternal hematopoietic cells had a significantly higher overall survival than patients receiving paternal grafts (60% vs 32%, P = 0.006). Although no significant difference was observed in the occurrence of severe acute GVHD (grade ⩾III) and the relapse of malignant diseases between two groups, the probability of non-relapse treatment-related mortality was significantly lower after maternal donor transplants. Furthermore, multivariate analysis revealed that parental donor type was the only factor significantly associated with overall survival. In conclusion, our analysis indicates superior survival of maternally donated recipients in hematopoietic stem-cell transplantations from biological parents. This finding has important implications in the selection of alternative familial donors, and warrants further prospective analysis of parental donor transplantations. Bone Marrow Transplantation (2001) 28, 375–380.

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Acknowledgements

This study was approved by the Committee for Nationwide Survey Data Management in the JSHCT as a working group (WG-2) and was presented in part at the 2000 Annual Meeting of the American Society of Hematology, San Francisco, CA, USA.23 We greatly thank Takashi Uchiyama, Hitoshi Ohno and Hiroh Saji for providing us with substantial advice on the writing of the paper. We also acknowledge all the JSHCT transplantation teams without whom the valuable data presented here would not have been collected.

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Authors and Affiliations

  1. Department of Internal Medicine, Yamada Red Cross Hospital, Misono, Japan

    S Tamaki

  2. Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan

    T Ichinohe

  3. Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan

    K Matsuo & N Hamajima

  4. Office of Nationwide Survey, Japan Society for Hematopoietic Cell Transplantation, Nagoya, Japan

    K Matsuo & N Hamajima

  5. Department of Hematology, Nagoya Daini Red Cross Hospital, Nagoya, Japan

    N Hirabayashi

  6. Department of Internal Medicine, Hiroshima Red Cross Hospital and Atomic Bomb Survivor's Hospital, Hiroshima, Japan

    H Dohy

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  1. S Tamaki
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Tamaki, S., Ichinohe, T., Matsuo, K. et al. Superior survival of blood and marrow stem cell recipients given maternal grafts over recipients given paternal grafts. Bone Marrow Transplant 28, 375–380 (2001). https://doi.org/10.1038/sj.bmt.1703146

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