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Hematopoietic stem cell transplantation between red cell incompatible donor–recipient pairs

Abstract

Transplantation between red cell-disparate donor and recipient is feasible with minimal increase in the risk of transplantation if consideration is given to the immunohematological consequences of the transplant. The risks of immediate and delayed hemolysis must be managed. Some recipients will experience a delay in the recovery of red blood cells. Bone Marrow Transplantation (2001) 28, 315–321.

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References

  1. Gale RP, Feig S, Ho W et al. ABO blood group system and bone marrow transplantation Blood 1977 50: 185–194

    CAS  PubMed  Google Scholar 

  2. Buckner CD, Clift RA, Sanders JE et al. ABO-incompatible marrow transplants Transplantation 1978 26: 233–238

    Article  CAS  PubMed  Google Scholar 

  3. Tippett P . Chromosome mapping of the blood group genes Semin Hematol 1981 18: 4–12

    CAS  PubMed  Google Scholar 

  4. Franchini M, de Gironcoli M, Gandini G et al. Transmission of an anti-RhD alloantibody from donor to recipient after ABO-incompatible BMT Bone Marrow Transplant 1998 21: 1071–1073

    Article  CAS  PubMed  Google Scholar 

  5. Leo A, Mytilineos J, Voso MT et al. Passenger lymphocyte syndrome with severe hemolytic anemia due to an anti-Jka after allogeneic PBPC transplantation Transfusion 2000 40: 632–636

    Article  CAS  PubMed  Google Scholar 

  6. Dinsmore RE, Reich LM, Kapoor N et al. ABH incompatible bone marrow transplantation: removal of erythrocytes by starch sedimentation Br J Haematol 1983 54: 441–449

    Article  CAS  PubMed  Google Scholar 

  7. Braine HG, Sensenbrenner LL, Wright SK et al. Bone marrow transplantation with major ABO blood group incompatibility using erythrocyte depletion of marrow prior to infusion Blood 1982 60: 420–425

    CAS  PubMed  Google Scholar 

  8. Sniecinski IJ, O'Donnell MR . Hemolytic complications of hematopoietic cell transplantation In: Thomas ED, Blume KG, Forman SJ (eds) Hematopoietic Cell Transplantation Blackwell Science: Malden 1999 pp 674–684

    Google Scholar 

  9. Marmont AM, Damasio EE, Bacigalupo A et al. A to O bone marrow transplantation in severe aplastic anaemia: dynamics of blood group conversion and demonstration of early dyserythropoiesis in the engrafted marrow Br J Haematol 1977 36: 511–518

    Article  CAS  PubMed  Google Scholar 

  10. Gmur JP, Burger, J, Schaffner A et al. Pure red cell aplasia of long duration complicating major ABO-incompatible bone marrow transplantation Blood 1990 75: 290–295

    CAS  PubMed  Google Scholar 

  11. Worel N, Greinix HT, Schneider B et al. Regeneration of erythropoiesis after related- and unrelated-donor BMT or peripheral blood HPC transplantation: a major ABO mismatch means problems Transfusion 2000 40: 543–550

    Article  CAS  PubMed  Google Scholar 

  12. Benjamin RJ, Connors JM, McGurk S et al. Prolonged erythroid aplasia after major ABO-mismatched transplantation for chronic myelogenous leukemia Biol Blood Marrow Transplant 1998 4: 151–156

    Article  CAS  PubMed  Google Scholar 

  13. Bar BMAM, Van Dijk BA, Schattenberg A et al. Erythrocyte repopulation after major ABO incompatible transplantation with lymphocyte-depleted bone marrow Bone Marrow Transplant 1995 16: 793–799

    CAS  PubMed  Google Scholar 

  14. Hows J, Beddow K, Gordon-Smith E et al. Donor-derived red blood cell antibodies and immune hemolysis after allogeneic bone marrow transplantation Blood 1986 67: 177–181

    CAS  PubMed  Google Scholar 

  15. Gajewski JL, Petz LD, Calhoun L et al. Hemolysis of transfusion group O red blood cells in minor ABO-incompatible unrelated-donor bone marrow transplants in patients receiving cyclosporine without posttransplant methotrexate Blood 1992 79: 3076–3085

    CAS  PubMed  Google Scholar 

  16. Greeno EW, Perry EH, Ilstrup SJ, Weisdorf DJ . Exchange transfusion the hard way: massive hemolysis following transplantation of bone marrow with minor ABO incompatibility Transfusion 1996 36: 71–74

    Article  CAS  PubMed  Google Scholar 

  17. Toren A, Dacosta Y, Manny N et al. Passenger B-lymphocyte-induced severe hemolytic disease after allogeneic peripheral blood stem cell transplantation Blood 1996 87: 843–844

    CAS  PubMed  Google Scholar 

  18. Bornhauser M, Ordemann R, Paaz U et al. Rapid engraftment after allogeneic ABO-incompatible peripheral blood stem cell transplantation complicated by severe hemolysis Bone Marrow Transplant 1997 19: 295–297

    Article  CAS  PubMed  Google Scholar 

  19. Laurencet FM, Samii K, Bressoud A et al. Massive delayed hemolysis following peripheral blood stem cell transplantation with minor ABO incompatibility Hematol Cell Ther 1997 39: 159–162

    Article  CAS  PubMed  Google Scholar 

  20. Oziel-Taieb S, Faucher-Barbey C, Chabannon C et al. Early and fatal immune haemolysis after so-called ‘minor’ ABO-incompatible peripheral blood stem cell allotransplantation Bone Marrow Transplant 1997 19: 1155–1156

    Article  CAS  PubMed  Google Scholar 

  21. Salmon JP, Michaux S, Hermanne JP et al. Delayed massive immune hemolysis mediated by minor ABO incompatibility after allogeneic peripheral blood progenitor cell transplantation Transfusion 1999 39: 824–827

    Article  CAS  PubMed  Google Scholar 

  22. Rowley SD, Liang PS, Ulz L . Transplantation of ABO-incompatible bone marrow and peripheral blood stem cell components Bone Marrow Transplant 2000 26: 749–757

    Article  CAS  PubMed  Google Scholar 

  23. Benjamin RJ, McGurk S, Ralson MS, Churchill WH, Antin JH . ABO incompatibility as an adverse risk factor for survival after allogeneic bone marrow transplantation Transfusion 1999 39: 179–187

    Article  CAS  PubMed  Google Scholar 

  24. Benjamin RJ, Antin JH . ABO-incompatible bone marrow transplantation: the transfusion of incompatible plasma may exacerbate regimen-related toxicity Transfusion 1999 39: 1273–1274

    Article  CAS  PubMed  Google Scholar 

  25. Webb IJ, Soiffer RJ, Anderson JW et al. In vivo adsorption of isohemagglutinins with fresh frozen plasma in major ABO-incompatible bone marrow transplantation Biol Blood Marrow Transplant 1997 3: 267–272

    CAS  PubMed  Google Scholar 

  26. Standards for Blood Banks and Transfusion Services 18th edn American Association of Blood Banks: Bethesda, MD 1997

  27. Rodriquez JM, Carmona M, Noguerol P et al. A fully automated method for mononuclear bone marrow cell concentration J Clin Apheresis 1992 7: 101–109

    Article  Google Scholar 

  28. Davis JM, Schepers KG, Eby LL, Noga SJ . Comparison of progenitor cell concentration techniques: continuous flow separation versus density-gradient isolation J Hematother 1993 2: 315–320

    Article  CAS  PubMed  Google Scholar 

  29. Zingsem J, Zeiler T, Zimmermann R et al. Bone marrow processing with the Fresenius AS 104: initial results J Hematother 1992 1: 273–278

    Article  CAS  PubMed  Google Scholar 

  30. Dinsmore RE, Reich LM, Kapoor N et al. ABH incompatible bone marrow transplantation: removal of erythrocytes by starch sedimentation Br J Haematol 1983 54: 441–449

    Article  CAS  PubMed  Google Scholar 

  31. Sierra J, Storer B, Hansen JA et al. Transplantation of marrow cells from unrelated donors for treatment of high-risk acute leukemia: the effect of leukemic burden, donor HLA-matching, and marrow cell dose Blood 1997 89: 4226–4235

    CAS  PubMed  Google Scholar 

  32. Warkentin PI, Yomtovian R, Hurd D et al. Severe delayed hemolytic transfusion reaction complicating an ABO-incompatible bone marrow transplantation Vox Sang 1983 45: 40–47

    Article  CAS  PubMed  Google Scholar 

  33. Karhi KK, Andersson LC, Vuopio P, Bahmberg CG . Expression of blood group A antigens in human bone marrow cells Blood 1981 57: 147–151

    CAS  PubMed  Google Scholar 

  34. Lopez A, de la Rubia J, Arriaga F et al. Severe hemolytic anemia due to multiple red cell alloantibodies after an ABO-incompatible allogeneic bone marrow transplant Transfusion 1998 38: 247–251

    Article  CAS  PubMed  Google Scholar 

  35. Sniecinski IJ, Oien L, Petz LD, Blume KG . Immunohematologic consequences of major ABO-mismatched bone marrow transplantation Transplantation 1988 45: 530–534

    Article  CAS  PubMed  Google Scholar 

  36. Mielcarek M, Leisenring W, Torok-Storb B, Storb R . Graft-versus-host disease and donor-directed hemagglutinin titers after ABO-mismatched related and unrelated marrow allografts: evidence for a graft-versus-plasma cell effect Blood 2000 96: 1150–1156

    CAS  PubMed  Google Scholar 

  37. Santamaria A, Sureda A, Martino R et al. successful treatment of pure red cell aplasia after major ABO-incompatible T cell-depleted bone marrow transplantation with erythropoietin Bone Marrow Transplant 1997 20: 1105–1107

    Article  CAS  PubMed  Google Scholar 

  38. Ohashi K, Akiyama H, Takamoto S et al. Treatment of pure red cell aplasia after major ABO-incompatible bone marrow transplantation resistant to erythropoietin Bone Marrow Transplant 1994 13: 335–336

    CAS  PubMed  Google Scholar 

  39. Labar B, Bogdanic V, Memet D et al. Antilymphocyte globulin for treatment of pure red cell aplasia after major ABO incompatible marrow transplant Bone Marrow Transplant 1992 10: 471–472

    CAS  PubMed  Google Scholar 

  40. Selleri C, Raiola A, De Rosa G et al. CD34+-enriched donor lymphocyte infusions in a case of pure red cell aplasia and late graft failure after major ABO-incompatible bone marrow transplantation Bone Marrow Transplant 1998 22: 605–607

    Article  CAS  PubMed  Google Scholar 

  41. Hazelhurst GR, Brenner MK, Wimperis JZ et al. Hemolysis after T-cell depleted bone marrow transplantation involving minor ABO incompatibility Scand J Haematol 1986 37: 1–3

    Article  Google Scholar 

  42. Rosental GJ, Weigand GW, Germolec DR et al. Suppression of B cell function by methotrexate and trimetrexate – evidence for inhibition of purine biosynthesis as a major mechanism of action J Immunol 1988 141: 410–416

    Google Scholar 

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Acknowledgements

The author wishes to thank Laura Ulz, RN and the staff of the Transfusion Service of the Fred Hutchinson Cancer Research Center, Seattle, WA for their expert help in developing the algorithms of support described in this manuscript.

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Rowley, S. Hematopoietic stem cell transplantation between red cell incompatible donor–recipient pairs. Bone Marrow Transplant 28, 315–321 (2001). https://doi.org/10.1038/sj.bmt.1703135

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