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Successful mismatched sibling cord blood transplant in Hb Bart's disease

Bone Marrow Transplantation volume 28, pages 105–107 (2001)Cite this article

Abstract

A 20-month-old girl with Hb Bart's disease, who had survived neonatal complications, underwent HLA-DR antigen mismatched sibling cord blood transplantation successfully. Immune thrombocytopenia, which occurred around 2.5 months after transplant, responded to intravenous γ-globulin. The fetal hemoglobin level rose to a peak of 52.3% on day +69 post transplant and declined gradually during the following year. Ten percent of hemoglobin Bart's was detected 2 months after transplant and this reflects the α-thalassemia trait of the donor. Bone Marrow Transplantation (2001) 28, 105–107.

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Authors and Affiliations

  1. Department of Pediatrics, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China

    X Zhou, SY Ha, GCF Chan & YL Lau

  2. Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China

    V Chan & RHS Liang

  3. Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China

    B Hawkins

  4. Department of Obstetrics and Gynecology, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China

    YH Lam

  5. Department of Paediatrics, Queen Elizabeth Hospital, Hong Kong SAR, China

    CW Luk

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  1. X Zhou
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  2. SY Ha
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Zhou, X., Ha, S., Chan, G. et al. Successful mismatched sibling cord blood transplant in Hb Bart's disease. Bone Marrow Transplant 28, 105–107 (2001). https://doi.org/10.1038/sj.bmt.1703104

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  • DOI: https://doi.org/10.1038/sj.bmt.1703104

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