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Successful unrelated bone marrow transplantation for a patient with chronic granulomatous disease and associated resistant pneumonitis and Aspergillus osteomyelitis

Bone Marrow Transplantation volume 28, pages 83–87 (2001)Cite this article

Abstract

We describe the successful treatment of a 20-year-old patient with chronic granulomatous disease (CGD), by unrelated bone marrow transplantation (UBMT). The patient is relatively old compared to other CGD patients treated with BMT. He had had repeated serious infections from early childhood and was diagnosed as CGD, gp91-phox deficiency. Prolonged antibiotic-resistant pneumonitis worsened when the patient was 18 years old. In addition, he suffered Aspergillus osteomyelitis and acute renal failure due to amphotericin B. He received 94 granulocyte transfusions from 94 adult donors and the infections gradually improved. In September 1998, at 20 years of age, he underwent UBMT from an HLA 6 antigen-matched male donor, with CY and TBI conditioning. He received MTX and CsA as prophylaxis against GVHD. No serious complications occurred and rapid engraftment was achieved. Acute GVHD (grade 2, at day 19) and chronic GVHD (limited, at day 192) occurred. However, both were easily controlled. The patient is alive and well with no late rejection 26 months after UBMT. Bone Marrow Transplantation (2001) 28, 83–87.

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Acknowledgements

We thank Prof Y Kobayashi, Dr S Taniuchi, A Yamamoto, M Hasui and S Tsuji (Dept of Pediatrics, Kansai Medical University) for performing the neutrophil function tests.

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  1. Department of Pediatrics, Hamamatsu University School of Medicine, Hamamatsu, Japan

    C Watanabe, S Yajima, T Taguchi, K Toya, Y Fujii, T Hongo & T Ohzeki

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  1. C Watanabe
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  2. S Yajima
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Watanabe, C., Yajima, S., Taguchi, T. et al. Successful unrelated bone marrow transplantation for a patient with chronic granulomatous disease and associated resistant pneumonitis and Aspergillus osteomyelitis. Bone Marrow Transplant 28, 83–87 (2001). https://doi.org/10.1038/sj.bmt.1703086

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