Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Viral Complications

Respiratory syncytial virus infection in the late bone marrow transplant period: report of three cases and review

Abstract

Respiratory syncytial virus (RSV) infection is an important cause of respiratory mortality in immunosuppressed patients, including bone marrow transplant (BMT) recipients. The presence of lower respiratory tract infection and infection in the pre-engraftment phase of BMT is believed to confer a poor prognosis. Three patients who underwent allogeneic BMT at our institution developed RSV pneumonia over 1 year post BMT, with the underlying disease in remission. All three were hypoxic with extensive pulmonary disease at presentation. Treatment consisted of aerosolized ribavirin and intravenous immune globulin with successful clearing of viral shedding and excellent clinical outcomes. RSV infection is probably less severe in the late post-BMT period, but needs to be considered early in the differential diagnosis of pulmonary infiltrates in this patient population. Bone Marrow Transplantation (2001) 27, 1071–1073.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

References

  1. Whimbey E, Englund JA, Couch RB . Community respiratory virus infections in immunocompromised patients with cancer Am J Med 1997 102: 10–18

    Article  CAS  Google Scholar 

  2. Harrington RD, Hooton TM, Hackman RC et al. An outbreak of respiratory syncytial virus in a bone marrow transplant center J Infect Dis 1992 165: 987–993

    Article  CAS  Google Scholar 

  3. McColl MD, Corser RB, Bremmer J et al. Respiratory syncitial virus infection in adult BMT recipients: effective therapy with short duration nebulised ribavirin Bone Marrow Transplant 1998 21: 423–425

    Article  CAS  Google Scholar 

  4. McCarthy AJ, Kingman HM, Kelly C et al. The outcome of 26 patients with respiratory syncytial virus infection following allogeneic stem cell transplantation Bone Marrow Transplant 1999 24: 1315–1322

    Article  CAS  Google Scholar 

  5. Hertz MI, Englund JA, Snover D et al. Respiratory syncytial virus-induced acute lung injury in adult patients with bone marrow transplants: a clinical approach and review of the literature Medicine 1989 68: 269–281

    Article  CAS  Google Scholar 

  6. Meyers JD, Flournoy N, Thomas ED . Nonbacterial pneumonia after allogeneic marrow transplantation: a review of ten years’ experience Rev Infect Dis 1982 4: 1119–1132

    Article  CAS  Google Scholar 

  7. Whimbey E, Champlin RE, Couch RB et al. Community respiratory virus infections among hospitalized adult bone marrow transplant recipients Clin Infect Dis 1996 22: 778–782

    Article  CAS  Google Scholar 

  8. Ljungman P, Gleaves CA, Meyers JD . Respiratory virus infection in immunocompromised patients Bone Marrow Transplant 1989 4: 35–40

    CAS  PubMed  Google Scholar 

  9. Englund JA, Sullivan CJ, Colin Jordan M et al. Respiratory syncytial virus infection in immunocompromised adults Ann Intern Med 1988 109: 203–208

    Article  CAS  Google Scholar 

  10. Ghosh S, Champlin RE, Englund J et al. Respiratory syncytial virus upper respiratory tract illnesses in adult blood and marrow transplant recipients: combination therapy with aerosolized ribavirin and intravenous immunoglobulin Bone Marrow Transplant 2000 25: 751–755

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Khushalani, N., Bakri, F., Wentling, D. et al. Respiratory syncytial virus infection in the late bone marrow transplant period: report of three cases and review. Bone Marrow Transplant 27, 1071–1073 (2001). https://doi.org/10.1038/sj.bmt.1703046

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/sj.bmt.1703046

Keywords

  • RSV infection
  • late
  • BMT
  • ribavirin

This article is cited by

Search

Quick links