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Myositis, polyserositis with a large pericardial effusion and constrictive pericarditis as manifestations of chronic graft-versus-host disease after non-myeloablative peripheral stem cell transplantation and subsequent donor lymphocyte infusion

Bone Marrow Transplantation volume 27, pages 231–233 (2001)Cite this article

Abstract

The clinical features of chronic graft-versus-host disease (cGVHD) following a non-myeloablative peripheral blood stem cell (PBSC) transplant may differ from those that occur after a conventional allograft. We describe a man with Hodgkin's disease refractory to chemotherapy and radiotherapy who was transplanted from an HLA-identical brother, who developed cGVHD characterised, in particular, by polymyositis, polyserositis with a large pericardial effusion and constrictive pericarditis, 1 month after donor lymphocyte infusion for relapsed disease. Constrictive pericarditis has not been previously reported after a conventional allograft, and none of these features have been reported after a non-myeloablative transplant. The course of cGVHD necessitated potent immunosuppression leading to the presumed loss of graft-versus-lymphoma (GVL) effect. Bone Marrow Transplantation (2001) 27, 231–233.

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Authors and Affiliations

  1. Department of Haematological Oncology, St Bartholomew's Hospital, London, UK

    L Silberstein, A Davies, S Kelsey, J Foran, C Murrell & J Cavenagh

  2. Department of Rheumatology, St Bartholomew's Hospital, London, UK

    D D'Cruz

  3. Department of Diagnostic Imaging, St Bartholomew's Hospital, London, UK

    S Vinnicombe

  4. Department of Histopathology, St Bartholomew's Hospital, London, UK

    A Norton

Authors
  1. L Silberstein
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  2. A Davies
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  3. S Kelsey
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  5. C Murrell
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  9. J Cavenagh
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Silberstein, L., Davies, A., Kelsey, S. et al. Myositis, polyserositis with a large pericardial effusion and constrictive pericarditis as manifestations of chronic graft-versus-host disease after non-myeloablative peripheral stem cell transplantation and subsequent donor lymphocyte infusion. Bone Marrow Transplant 27, 231–233 (2001). https://doi.org/10.1038/sj.bmt.1702775

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  • DOI: https://doi.org/10.1038/sj.bmt.1702775

Keywords

  • polyserositis
  • pericardial effusion
  • constrictive pericarditis
  • myositis
  • graft-versus-host disease

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