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Detection of EBV DNA in the cord blood donor for a patient developing Epstein–Barr virus-associated lymphoproliferative disorder following mismatched unrelated umbilical cord blood transplantation

Bone Marrow Transplantation volume 27, pages 761–765 (2001)Cite this article

Abstract

Epstein–Barr virus-associated post-transplant lymphoproliferative disorder (PTLD) has been well described as a complication following allogeneic stem cell transplantation but has only recently been reported following umbilical cord blood (UCB) transplant. We report the case of a child transplanted with unrelated mismatched UCB for juvenile chronic myelogenous leukemia (JCML) who developed EBV-associated PTLD, which was confirmed pathologically, 139 days following stem cell infusion. There was no clinical response to reduction of immune suppression, high-dose acyclovir, or alpha interferon. The patient died 160 days after transplantation. EBV was detected by polymerase chain reaction in the cord blood unit used for transplantation. This case demonstrates that EBV-associated PTLD can occur following mismatched unrelated UCB transplant and may be related to transmission of EBV infection by donor lymphocytes. Bone Marrow Transplantation (2001) 27, 761–765.

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Acknowledgements

We thank Pablo Rubinstein, New York Blood Center, NYC, NY; Barbara Schmeckpeper, Immunogenetics Laboratories, Johns Hopkins University Medical School; and Ben Z Katz, Division of Infectious Diseases, Children's Memorial Hospital, Northwestern University Medical School, Chicago, IL.

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Authors and Affiliations

  1. Division of Hematology/Oncology, Department of Pediatrics, Northwestern University Medical School, Children's Memorial Hospital, Chicago, IL, USA

    PR Haut, D Walterhouse & M Kletzel

  2. Department of Pathology, Cook County Hospital, Chicago, IL, USA

    P Kovarik

  3. Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    PH Shaw

  4. Departments of Pediatrics and Microbiology, University of Texas Health Science Center, San Antonio, TX, USA

    HB Jenson

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  1. PR Haut
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Haut, P., Kovarik, P., Shaw, P. et al. Detection of EBV DNA in the cord blood donor for a patient developing Epstein–Barr virus-associated lymphoproliferative disorder following mismatched unrelated umbilical cord blood transplantation. Bone Marrow Transplant 27, 761–765 (2001). https://doi.org/10.1038/sj.bmt.1702770

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