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Allografting

Allogeneic bone marrow transplantation in children failing prior autologous bone marrow transplantation

Bone Marrow Transplantation volume 27, pages 155–162 (2001)Cite this article

Abstract

Twenty-three children with de novo acute myelogenous leukemia (AML) (n= 20), secondary AML (n = 1), or non-Hodgkin's lymphoma (NHL) (n = 2) underwent allogeneic bone marrow transplantation (alloBMT) for graft failure (n = 1) or recurrent malignancy (n = 22) between February 1992 and August 1999 following autologous BMT (ABMT). Induction chemotherapy was given to 14 patients and nine patients went directly to alloBMT. Five received marrow from matched siblings, 14 from matched unrelated donors and four from mismatched family members. Conditioning regimens included cyclophosphamide, cytarabine, and total body irradiation. Nine patients are alive disease-free between 627 and 2433 days (1.7–6.7 years) post BMT resulting in a 4-year DFS of 39%. Eight patients relapsed at a median of 206 days (range, 35–669 days) post alloBMT and all eventually died. Eight patients (two of whom also relapsed) died of RRT. Although RRT and relapse remain significant problems, a significant percentage of pediatric patients failing ABMT may be cured with alloBMT. Bone Marrow Transplantation (2001) 27, 155–162.

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Acknowledgements

We would like to thank Margaret Aymond, Cynthia Walker, Patricia Johnson and Frances Curran for data collection, and Stacye Richardson for data management and review. This work was supported in part by cancer center grant P 30CA 21765 from the National Cancer Institute and by the American Lebanese Syrian Associated Charities (ALSAC).

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Authors and Affiliations

  1. Division of Bone Marrow Transplantation, Department of Hematology/Oncology, St Jude Children's Research Hospital, Memphis, TN, USA

    GA Hale, E Benaim, JM Cunningham, HE Heslop, EM Horwitz, W Leung, RJ Rochester, PD Shearer, JP Woodard & LC Bowman

  2. Department of Pediatrics, University of Tennessee College of Medicine, Memphis, TN, USA

    GA Hale, E Benaim, JM Cunningham, HE Heslop, EM Horwitz, W Leung, PD Shearer, JP Woodard & LC Bowman

  3. Department of Biostatistics, St Jude Children's Research Hospital, Memphis, TN, USA

    Xin Tong & DK Srivastava

  4. Division of Experimental Hematology, St Jude Children's Research Hospital, Memphis, TN, USA

    JM Cunningham & EM Horwitz

  5. Center for Cell and Gene Therapy, Baylor College of Medicine, 1102 Bates St, Suite 1100, Houston, TX 77030, USA

    HE Heslop

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Hale, G., Tong, X., Benaim, E. et al. Allogeneic bone marrow transplantation in children failing prior autologous bone marrow transplantation. Bone Marrow Transplant 27, 155–162 (2001). https://doi.org/10.1038/sj.bmt.1702765

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