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Acute Lymphoblastic Leukaemia

Improved outcome of adult T cell leukemia/lymphoma with allogeneic hematopoietic stem cell transplantation

Bone Marrow Transplantation volume 27, pages 15–20 (2001)Cite this article

Abstract

Adult T cell leukemia/lymphoma (ATL) is a poor prognosis T cell malignancy. In order to improve the outcome, we employed allogeneic stem cell transplantation (allo-SCT) for ATL in 10 patients, nine of whom were from HLA-identical siblings and one from an unrelated donor. Conditioning regimens varied among the patients except that all received total body irradiation. The patients tolerated the regimens well with mild, if any toxicity, and engraftment occurred in all cases. Median leukemia-free survival after allo-SCT was 17.5+ months (range 3.7–34.4+). Six of the 10 patients developed acute GVHD (one case each with grade I, III or IV, and three cases with grade II) and three patients developed extensive chronic GVHD. Four patients died after allo-SCT during the study period from either acute GVHD (grade IV), pneumonitis, gastrointestinal bleeding or renal insufficiency. Two of the 10 cases with no symptoms of GVHD relapsed with clinical ATL. These results strongly suggest that allo-SCT may improve the survival in ATL if a controlled degree of GVHD develops. Bone Marrow Transplantation (2001) 27, 15–20.

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Acknowledgements

We would like to thank Dr I Sanada (Institute for Clinical Research, Kumamoto National Hospital), Dr E Ohtsuka (Second Department of Internal Medcine, Oita Medical University), Dr E Ohno (Department of Hematology, Oita Prefectural Hospital), Dr Y Nawa (Division of Internal Medicine and Hematology, Ehime Prefectural Central Hospital), Dr H Taji (Department of Hematology and Chemotherapy, Aichi Cancer Center) and Dr Y Atsuta (Division of Hematology, Japanese Red Cross Nagoya First Hospital) for providing information on ATL patients who received allo-SCT.

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Authors and Affiliations

  1. Department of Hematology, Imamura Bun-in Hospital, Kagoshima, Japan

    A Utsunomiya & Y Takatsuka

  2. Department of Hematology, Molecular Medicine Unit, Atomic Disease Institute, Nagasaki University School of Medicine, Nagasaki, Japan

    Y Miyazaki & M Tomonaga

  3. Second Department of Internal Medicine, Faculty of Medicine, Kagoshima University, Kagoshima, Japan

    S Hanada & K Uozumi

  4. Department of Virology, Faculty of Medicine, Kagoshima University, Kagoshima, Japan

    S Yashiki & S Sonoda

  5. Internal Medicine, Kagoshima City Hospital, Kagoshima, Japan

    M Tara

  6. Institute for Clinical Research, Kumamoto National Hospital, Kumamoto, Japan

    F Kawano

  7. Department of Hematology, Oita Prefectural Hospital, Oita, Japan

    Y Saburi

  8. Blood Transfusion Service, Oita Medical University, Oita, Japan

    H Kikuchi

  9. Division of Internal Medicine and Hematology, Ehime Prefectural Central Hospital, Matsuyama, Japan

    M Hara

  10. Department of Hematology, Meitetsu Hospital, Nagoya, Japan

    H Sao

  11. Department of Hematology and Chemotherapy, Aichi Cancer Center, Nagoya, Japan

    Y Morishima

  12. Division of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan

    Y Kodera

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  1. A Utsunomiya
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  2. Y Miyazaki
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  5. K Uozumi
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  6. S Yashiki
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  9. Y Saburi
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  10. H Kikuchi
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  11. M Hara
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  12. H Sao
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  14. Y Kodera
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  15. S Sonoda
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  16. M Tomonaga
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Utsunomiya, A., Miyazaki, Y., Takatsuka, Y. et al. Improved outcome of adult T cell leukemia/lymphoma with allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 27, 15–20 (2001). https://doi.org/10.1038/sj.bmt.1702731

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  • DOI: https://doi.org/10.1038/sj.bmt.1702731

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