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Allogeneic stem cell transplantation in a patient with refractory Burkitt's lymphoma using non-myeloablative conditioning regimen

Bone Marrow Transplantation volume 26, pages 1351–1354 (2000)Cite this article

Abstract

We have performed an allogeneic stem cell transplant in an 18-year-old male patient who had Burkitt's lymphoma. The patient had disease which was refractory to conventional intensive chemotherapy and radiation therapy. High-dose chemotherapy with autologous stem cell rescue was given but the patient relapsed within 2 months after transplantation. He was then treated with allogeneic stem cell transplantation using a fludarabine, busulfan and anti-thymocyte globulin-based conditioning regimen. His GVHD prophylaxis included mycophenolate and tacrolimus. The patient had engraftment within 14 days. Investigation by FISH showed more than 95% of his peripheral blood nucleated cells to be of donor origin since day +14. He is now alive and well and remains disease-free 6-months after the transplant. A graft-versus-lymphoma effect is thought to be one of the factors contributing to his remission. Bone Marrow Transplantation (2000) 26, 1351–1354.

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References

  1. Sweetenham JW, Pearce R, Taghipour G et al. Adult Burkitt's and Burkitt-like non-Hodgkin's lymphoma – outcome for patients treated with high-dose therapy and autologous stem-cell transplantation in first remission or at relapse: results from the European Group for Blood and Marrow Transplantation J Clin Oncol 1996 14: 2465–2472

    Article  CAS  PubMed  Google Scholar 

  2. Ladenstein R, Pearce R, Hartmann O et al. High-dose chemotherapy with autologous bone marrow rescue in children with poor-risk Burkitt's lymphoma: a report from the European Lymphoma Bone Marrow Transplantation Registry Blood 1997 90: 2921–2930

    CAS  PubMed  Google Scholar 

  3. Kolb HJ, Schattenberg A, Goldman JM et al. Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. European Group for Blood and Marrow Transplantation Working Party Chronic Leukemia Blood 1995 86: 2041–2050

    CAS  PubMed  Google Scholar 

  4. de Lima M, van Besien KW, Giralt SA et al. Bone marrow transplantation after failure of autologous transplant for non-Hodgkin's lymphoma Bone Marrow Transplant 1997 19: 121–127

    Article  CAS  PubMed  Google Scholar 

  5. McMaster ML, Greer JP, Greco FA et al. Effective treatment of small-noncleaved-cell lymphoma with high-intensity brief duration chemotherapy J Clin Oncol 1991 9: 941–946

    Article  CAS  PubMed  Google Scholar 

  6. Schwenn MR, Blattner SR, Lynch E, Weinstein HJ . HiC-COM a 2-month intensive chemotherapy regimen for children with stage III and IV Burkitt's lymphoma and B-cell acute lymphoblastic leukemia J Clin Oncol 1991 9: 133–138

    Article  CAS  PubMed  Google Scholar 

  7. Horowitz MM, Gale RP, Sondel PM et al. Graft-versus-leukemia reactions after bone marrow transplantation Blood 1990 75: 555–562

    CAS  PubMed  Google Scholar 

  8. Kolb HJ, Mittermuller J, Clemm C et al. Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients Blood 1990 76: 2462–2465

    CAS  PubMed  Google Scholar 

  9. Slavin S, Nagler A, Naparstek E et al. Nonmyeloablative stem cell transplantation and cell therapy as an alternative toconventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignanthematologic diseases Blood 1998 91: 756–763

    CAS  PubMed  Google Scholar 

  10. Giralt S, Estey E, Albitar M et al. Engraftment of allogeneic hematopoietic progenitor cells with purine analog-containing chemotherapy: harnessing graft-versus-leukemia without myeloablative therapy Blood 1997 89: 4531–4536

    CAS  PubMed  Google Scholar 

  11. Khouri IF, Keating M, Korbling M et al. Transplant-lite: induction of graft-versus-malignancy using fludarabine-based nonablative chemotherapy and allogeneic blood progenitor-cell transplantation as treatment for lymphoid malignancies J Clin Oncol 1998 16: 2817–2824

    Article  CAS  PubMed  Google Scholar 

  12. Grigg A, Bardy P, Byron K et al. Fludarabine-based non-myeloablative chemotherapy followed by infusion of HLA-identical stem cells for relapsed leukaemia and lymphoma Bone Marrow Transplant 1999 23: 107–110

    Article  CAS  PubMed  Google Scholar 

  13. Sykes M, Preffer F, McAfee S et al. Mixed lymphohaemopoietic chimerism and graft-versus-lymphoma effects after non-myeloablative therapy and HLA-mismatched bone-marrow transplantation Lancet 1999 353: 1755–1759

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

We would like to thank Dr Voravit Ratanatharathorn from University of Michigan, Ann Arbor, MI, who kindly gave us valuable advice and shared with us his experience of using non-myeloablative regimen.

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Authors and Affiliations

  1. Bone Marrow Transplantation Unit, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

    A Ungkanont & S Jootar

  2. Division of Hematology, Department of Medicine Pramongkutklau Hospital, Bangkok, Thailand

    W Mongkonsritrakoon

  3. Vichaiyut Hospital, Bangkok, Thailand

    T Srichaikul

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  1. A Ungkanont
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  2. W Mongkonsritrakoon
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  3. S Jootar
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  4. T Srichaikul
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Ungkanont, A., Mongkonsritrakoon, W., Jootar, S. et al. Allogeneic stem cell transplantation in a patient with refractory Burkitt's lymphoma using non-myeloablative conditioning regimen. Bone Marrow Transplant 26, 1351–1354 (2000). https://doi.org/10.1038/sj.bmt.1702730

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  • DOI: https://doi.org/10.1038/sj.bmt.1702730

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