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Cytomegalovirus pneumonitis, activated prothrombin time prolongation and subacute thyroiditis after unrelated allogeneic bone marrow transplantation

Abstract

A 22-year-old female with acute myeloid leukemia (AML) in complete remission received a conditioning regimen containing antithymocyte globulin for an unrelated bone marrow transplant (BMT). After BMT, the patient suffered from cytomegalovirus (CMV) pneumonitis with markedly high levels of CMV antigenemia, activated prothrombin time (APTT) prolongation, and subacute thyroiditis. Recovery of CD4+ cells was delayed as long as 1 year after BMT. An association between these three episodes and viral infection due to the delayed recovery of CD4+ cells is suggested. Bone Marrow Transplantation (2000) 26, 1347–1349.

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References

  1. Meyers JD, Flournoy N, Thomas ED . Risk factors for cytomegalovirus infection after human marrow transplantation J Infect Dis 1986 153: 478–488

    CAS  Article  Google Scholar 

  2. Rubie H, Attal M, Campardou AM et al. Risk factors for cytomegalovirus infection in BMT recipients transfused exclusively with seronegative blood products Bone Marrow Transplant 1993 11: 209–214

    CAS  PubMed  Google Scholar 

  3. Meyers JD, Ljungman P, Fisher LD . Cytomegalovirus excretion as a predictor of cytomegalovirus disease after marrow transplantation: importance of cytomegalovirus viremia J Infect Dis 1990 162: 373–380

    CAS  Article  Google Scholar 

  4. Torok-Storb B, Boeckh M, Hoy C et al. Association of specific cytomegalovirus genotypes with death from myelosuppression after marrow transplantation Blood 1997 90: 2097–2102

    CAS  PubMed  Google Scholar 

  5. The TH, van der Bij W, van den Berg AP et al. Cytomegalovirus antigenemia Rev Infect Dis 1990 12: (Suppl.7) 734–744

    Article  Google Scholar 

  6. van den Berg AP, van der Bij W, van Son WJ et al. Cytomegalovirus antigenemia as a useful marker of symptomatic cytomegalovirus infection after renal transplantation-a report of 130 consecutive patients Transplantation 1989 48: 991–995

    CAS  Article  Google Scholar 

  7. Beatty PG, Clift RA, Mickelson EM et al. Marrow transplantation from related donors other than HLA-identical siblings New Engl J Med 1985 313: 765–771

    CAS  Article  Google Scholar 

  8. Kernan NA, Bartsch G, Ash RC et al. Analysis of 462 transplantations from unrelated donors facilitated by the National Marrow Donor Program New Engl J Med 1993 328: 593–602

    CAS  Article  Google Scholar 

  9. Kodera Y, Morishima Y, Kato S et al. Analysis of 500 bone marrow transplants from unrelated donors (UR-BMT) facilitated by the Japan Marrow Donor Program: confirmation of UR-BMT as a standard therapy for patients with leukemia and aplastic anemia Bone Marrow Transplant 1999 24: 995–1003

    CAS  Article  Google Scholar 

  10. Tomer Y, Davies TF . Infection, thyroid disease, and autoimmunity Endocr Rev 1993 14: 107–120

    CAS  PubMed  Google Scholar 

  11. Luotola K, Hyoty H, Salmi J et al. Evaluation of infectious etiology in subacute thyroiditis-lack of association with coxsackievirus infection APMIS 1998 106: 500–504

    CAS  Article  Google Scholar 

  12. Jones L, Ball J, Apperley JF et al. Subacute thyroiditis after bone marrow transplantation for chronic granulocytic leukemia Bone Marrow Transplant 1987 1: 411–412

    CAS  PubMed  Google Scholar 

  13. Wick G, Grubeck-Loebenstein B, Trieb K et al. Human foamy virus antigens in thyroid tissue of Graves’ disease patients Int Arch Allergy Immunol 1992 99: 153–156

    CAS  Article  Google Scholar 

  14. Coll J, Palazon J, Yazbeck-H et al. Antibodies to human immunodeficiency virus (HIV-1) in autoimmune diseases: primary Sjogren's syndrome, systemic lupus erythematosus, rheumatoid arthritis and autoimmune thyroid diseases Clin Rheumatol 1995 14: 451–457

    CAS  Article  Google Scholar 

  15. Ohsako N, Tamai H, Sudo T et al. Clinical characteristics of subacute thyroiditis classified according to human leukocyte antigen typing J Clin Endocrinol Metab 1995 80: 3653–3656

    CAS  Article  Google Scholar 

  16. Nurnberger W, Kruck H, Mauz-Korholz C et al. Humoral coagulation and early complications after allogeneic bone marrow transplantation Klin Padiatr 1997 209: 209–215

    CAS  Article  Google Scholar 

  17. Jaeger U, Kapiotis S, Pabinger I et al. Transient lupus anticoagulant associated with hypoprothrombinemia and factor XII deficiency following adenovirus infection Ann Hematol 1993 67: 95–99

    CAS  Article  Google Scholar 

  18. Kobayashi R, Kumon K, Watanabe N et al. Antithymocyte globulin as conditioning regimen for bone marrow transplantation Rinsho Ketsueki 1997 38: 1183–1188

    CAS  PubMed  Google Scholar 

  19. Yagasaki H, Kojima S, Inaba J et al. Clinical trial of antithymocyte globulin for prophylaxis of acute graft-versus-host disease in pediatric recipients of bone marrow transplantation from unrelated donors Rinsho Ketsueki 1999 40: 382–389

    CAS  PubMed  Google Scholar 

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Kawano, C., Muroi, K., Akioka, T. et al. Cytomegalovirus pneumonitis, activated prothrombin time prolongation and subacute thyroiditis after unrelated allogeneic bone marrow transplantation. Bone Marrow Transplant 26, 1347–1349 (2000). https://doi.org/10.1038/sj.bmt.1702711

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  • DOI: https://doi.org/10.1038/sj.bmt.1702711

Keywords

  • bone marrow transplantation
  • antithymocyte globulin
  • viral infection
  • CD4+ cells

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