Abstract
Despite detailed evaluation of disease-associated prognostic factors, little is known about the impact of overweight in autograft programs for non-Hodgkin's lymphoma (NHL) patients. In order to address this issue, 121 NHL patients were retrospectively evaluated. They had been upfront (92 patients) or in relapse (29 patients) and received high-dose sequential (HDS) chemotherapy including peripheral blood progenitor cell (PBPC) autograft. Body mass index (BMI) was calculated as weight in kilograms divided by the square of the height in meters; overweight was defined as BMI ⩾28. Univariate and multivariate analyses were used to determine the prognostic implication of overweight and other known prognostic indicators on overall (OS) and event-free (EFS) survival for the entire group and overweight and non-overweight (reference) subgroups. With a median follow-up of 3 years, the estimated 5-year OS and EFS for the entire group were 58% and 49%, respectively. Twenty-eight patients (23%) had BMI ⩾28. Their median OS and EFS were 2.2 and 1.4 years, respectively, whereas median OS and EFS for the reference group have not been reached, with a 5-year projection of 65 and 55%, respectively (P < 0.002). On multivariate analysis, the risk of death among overweight patients was 2.9 (CI, 1.3–6.2) times that of the reference group; using EFS as the end point, a similar association between overweight and survival was observed. In conclusion, in high-risk NHL patients undergoing intensive chemotherapy and PBPC autografting overweight is associated with a poorer outcome. Bone Marrow Transplantation (2000) 26, 1185–1191.
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Acknowledgements
We thank the medical staff and nurses of the Divisione Universitaria di Ematologia, of the Centro Dipartimentale Trapianto Midollo and of the Blood Bank, S Giovanni Hospital, Torino, Italy. This work was supported in part by Consiglio Nazionale delle Ricerche, Rome, Italy (special project ACRO, grant No. 96.00742.PF39 to TC and No. 96.00615.PF39 to AP) and by Associazione Italiana Ricerca sul Cancro, Milan, Italy.
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Tarella, C., Caracciolo, D., Gavarotti, P. et al. Overweight as an adverse prognostic factor for non-Hodgkin's lymphoma patients receiving high-dose chemotherapy and autograft. Bone Marrow Transplant 26, 1185–1191 (2000). https://doi.org/10.1038/sj.bmt.1702692
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DOI: https://doi.org/10.1038/sj.bmt.1702692
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