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Acquired Pelger–Huët anomaly in association with concomitant tacrolimus and fluconazole therapy following allogeneic bone marrow transplantation

Bone Marrow Transplantation volume 26, pages 1255–1257 (2000)Cite this article

Abstract

A 38-year-old Japanese woman with severe aplastic anemia received an allogeneic bone marrow transplant from her serologically HLA-identical father. Cyclosporine and methotrexate were administered to prevent graft-versus-host disease (GVHD). However, grade III acute GVHD developed on day 44, which was successfully treated with methylprednisolone and tacrolimus. Fluconazole therapy was started for oral candidiasis on day 112, but she complained of headache soon after. In addition to glycosuria and increased serum creatinine levels, Pelger–Huët anomaly of granulocytes was found in her blood, which disappeared after discontinuation of tacrolimus. Transient occurrence of Pelger–Huët cells may be associated with tacrolimus toxicity due to drug interaction with fluconazole. Bone Marrow Transplantation (2000) 26, 1255–1257.

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Acknowledgements

This work was supported in part by the Grant-in-Aid for Cancer Research (7–3) from the Ministry of Health and Welfare.

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  1. Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan

    H Gondo, C Okamura, K Osaki, K Shimoda, Y Asano & T Okamura

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  1. H Gondo
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  2. C Okamura
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  3. K Osaki
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  4. K Shimoda
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Gondo, H., Okamura, C., Osaki, K. et al. Acquired Pelger–Huët anomaly in association with concomitant tacrolimus and fluconazole therapy following allogeneic bone marrow transplantation. Bone Marrow Transplant 26, 1255–1257 (2000). https://doi.org/10.1038/sj.bmt.1702682

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