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An immunological syndrome featuring transverse myelitis, Evans syndrome and pulmonary infiltrates after unrelated bone marrow transplant in a patient with severe aplastic anemia

Bone Marrow Transplantation volume 26, pages 1225–1228 (2000)Cite this article

Abstract

A patient with severe aplastic anemia underwent a matched unrelated bone marrow transplant, following which he developed a complex autoimmune syndrome. This featured transverse myelitis, immune mediated Coombs positive hemolytic anemia and immune thrombocytopenia (Evans syndrome), pulmonary infiltrates, eosinophilia, muscle pains and cramps and lichenoid dermatitis all of which may represent manifestations of graft-versus-host disease as they showed response to immunosuppression. Thus, although immune-mediated cytopenias after an allogeneic bone marrow transplant are rare, they should be considered as a possible cause of cytopenia in post-transplant patients. Bone Marrow Transplantation (2000) 26, 1225–1228.

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Authors and Affiliations

  1. Division of Hematology, Department of Medicine, Mount Sinai Medical Center, New York, NY, USA

    S Richard, S Fruchtman, E Scigliano, V Najfeld & L Isola

  2. Department of Pathology, Transfusion Medicine, College of Physicians and Surgeons of Columbia University, New York, NY, USA

    D Skerrett

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  1. S Richard
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  2. S Fruchtman
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  3. E Scigliano
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  4. D Skerrett
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  5. V Najfeld
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  6. L Isola
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Richard, S., Fruchtman, S., Scigliano, E. et al. An immunological syndrome featuring transverse myelitis, Evans syndrome and pulmonary infiltrates after unrelated bone marrow transplant in a patient with severe aplastic anemia. Bone Marrow Transplant 26, 1225–1228 (2000). https://doi.org/10.1038/sj.bmt.1702677

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  • DOI: https://doi.org/10.1038/sj.bmt.1702677

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