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Post-Transplant Complications

No effect of nadroparin prophylaxis in the prevention of central venous catheter (CVC)-associated thrombosis in bone marrow transplant recipients

Bone Marrow Transplantation volume 26, pages 1103–1106 (2000)Cite this article

Abstract

Complications of CVCs in 382 consecutive patients receiving a stem cell transplantation (SCT) were analysed. Early complications were pneumothorax (3.6%), haematothorax (0.5%), dislocation (3%) and dysfunction (3.6%). Eighty-seven-associated infections (22%) were observed, leading to removal of the CVC in 26 patients. More bacteraemias were associated with double- or triple-lumen CVCs, 19% vs 5% in single lumen CVCs (P < 0.0001). Coagulase-negative staphylococci were the predominant microorganisms in 72%. A special point of investigation was CVC-associated thrombosis and the prophylactic value of nadroparin. Two consecutive regimens with nadroparin were used and compared; 7 days 2850 IE nadroparin and 10 days 5700 IE nadroparin. The incidence of CVC-associated thrombosis was 6.9% in 382 patients with 390 catheters. The incidence was 8% in patients receiving one of the prophylactic nadroparin regimens compared to 6% in a comparable control group without prophylaxis. A short course of nadroparin was unable to prevent thrombotic complications after discontinuation. Bone Marrow Transplantation (2000) 26, 1103–1106.

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References

  1. Hickman RO, Buckner DC, Clift RA et al. A modified right atrial catheter for access to the venous system in marrow transplant recipients Surg Gynecol Obstet 1979 148: 871–875

    CAS  PubMed  Google Scholar 

  2. Press OW, Ramsey PG, Larson EB et al. Hickman catheter infections in patients with malignancies Medicine 1984 63: 189–199

    Article  CAS  Google Scholar 

  3. Bozzetti F . Subclavian venous thrombosis secondary to indwelling catheters for parenteral nutrition Surg Italy 1977 7: 210–216

    Google Scholar 

  4. Bozzetti F, Scarpa D, Terno G et al. Subclavian venous thrombosis due to indwelling catheters: a prospective study on 52 patients J Parent Enter Nutr 1983 7: 560–562

    Article  CAS  Google Scholar 

  5. Haire WD, Lieberman RP, Edney J et al. Hickman catheter-induced thoracic vein thrombosis Cancer 1990 66: 900–908

    Article  CAS  Google Scholar 

  6. Laidlow JM, Powell-Tuck J, Wood SR et al. The use of a skin tunnelled silicone rubber catheter for parenteral feeding to avoid central venous thrombosis J Parent Enter Nutr 1980 4: 604 (Abstr.)

    Google Scholar 

  7. Ross AH, Griffith CD, Anderson JR, Grieve DC . Thromboembolic complications with silicone elastomer subclavian catheters J Parent Enter Nutr 1982 6: 61–63

    Article  CAS  Google Scholar 

  8. Pottecher T, Forrler M, Picardat P et al. Thrombogenicity of central venous catheters: prospective study of polyethylene, silicone and polyurethane catheters with phlebography or post-mortem examination Eur J Anaesthesiol 1984 1: 361–365

    CAS  PubMed  Google Scholar 

  9. Brismar B, Hardstedt C, Jacobson S et al. Reduction of catheter-associated thrombosis in parenteral nutrition by intravenous heparin therapy Arch Surg 1982 117: 1196–1199

    Article  CAS  Google Scholar 

  10. Blacklock HA, Pillai MV, Hill RS et al. Use of modified subcutaneous right-atrial catheter for venous access in leukaemic patients Lancet 1980 1: 993–994

    Article  CAS  Google Scholar 

  11. Ruggiero RP, Aisenstein TJ . Central catheter fibrin sleeve-heparin effect J Parent Enter Nutr 1983 7: 270–273

    Article  CAS  Google Scholar 

  12. Boraks P, Seale J, Price J et al. Prevention of central venous catheter associated thrombosis using minidose warfarin in patients with haematological malignancies Br J Haematol 1998 101: 483–486

    Article  CAS  Google Scholar 

  13. Drakos PE, Nagler A, Or R et al. Low molecular weight heparin for Hickman catheter-induced thrombosis in thrombocytopenic patients undergoing bone marrow transplantation Cancer 1992 70: 1895–1898

    Article  CAS  Google Scholar 

  14. Bern MM, Lokich JJ, Wallach SR et al. Very low dose of warfarin can prevent thrombosis in central venous catheters Ann Intern Med 1990 112: 423–428

    Article  CAS  Google Scholar 

  15. Elishoov H, Or R, Strauss N, Engelhard D . Nosocomial colonization, septicemia, and Hickman/Broviac catheter related infections in bone marrow transplant recipients Medicine 1998 77: 83–101

    Article  CAS  Google Scholar 

  16. Kappers-Klunne MC, Degener JE, Stijnen T, Abels J . Complication from long-term indwelling catheters in haematologic patients with special reference to infection Cancer 1989 64: 1747–1752

    Article  CAS  Google Scholar 

  17. Petersen FB, Clift RA, Hickman RO et al. Hickman catheter complications in marrow transplant recipients J Parent Enter Nutr 1986 10: 58–62

    Article  CAS  Google Scholar 

  18. Moosa HH, Julian TB, Rosenfeld CS, Shadduck RK . Complications of indwelling central venous catheters in bone marrow transplant recipients Surg Gynecol Obstet 1991 172: 275–279

    CAS  PubMed  Google Scholar 

  19. Vassilomanolakis M, Plataniotis G, Koumakis G et al. Central venous catheter-related infections after bone marrow transplantation in patients with malignancies: a prospective study with short-course vancomycin prophylaxis Bone Marrow Transplant 1995 15: 77–80

    CAS  PubMed  Google Scholar 

  20. Nouwen JL, Wielenga JJ, Overhagen van H et al. Hickman catheter-related infections in neutropenic patients: insertion in the operating theater versus insertion in the radiology suite J Clin Oncol 1999 17: 1304–1311

    Article  CAS  Google Scholar 

  21. Howell PB, Walters PE, Donowitz GR et al. Risk factors for infection of adult patients with cancer who have tunneled central venous catheters Cancer 1995 75: 1367–1375

    Article  CAS  Google Scholar 

  22. Turpie AG . Can we differentiate the low molecular weight heparins? Clin Cardiol 2000 23: (Suppl. 1) I4–I7

    Article  Google Scholar 

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Authors and Affiliations

  1. St Antonius Hospital Department of Pediatrics, Utrecht, The Netherlands

    SWJ Lagro

  2. UMC Department of Haematology, Utrecht, The Netherlands

    LF Verdonck & AW Dekker

  3. UMC Department of Surgery, Utrecht, The Netherlands

    IHM Borel Rinkes

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  1. SWJ Lagro
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  2. LF Verdonck
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  3. IHM Borel Rinkes
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  4. AW Dekker
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Lagro, S., Verdonck, L., Borel Rinkes, I. et al. No effect of nadroparin prophylaxis in the prevention of central venous catheter (CVC)-associated thrombosis in bone marrow transplant recipients. Bone Marrow Transplant 26, 1103–1106 (2000). https://doi.org/10.1038/sj.bmt.1702675

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