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Case Report

Philadelphia-positive T-ALL in a patient with follicular lymphoma

Bone Marrow Transplantation volume 26, pages 1113–1115 (2000)Cite this article

Abstract

Follicular lymphoma is a B cell malignancy prone to transformation into a large cell diffuse histology. This progression may be multi-clonal as determined by IgH rearrangement. Similar multi-clonal occurrences have been described in immunocompromised patients. However, the lymphoma cells remain predominantly of B cell type. Rarely, composite lymphomas with diffuse T cell histology have been reported arising from follicular lymphoma. The development of T cell leukaemia in a patient with a pre-existing B cell malignancy is an extremely rare event. The occurrence of T cell acute lymphoblastic leukaemia (T-ALL) following follicular lymphoma (FL) has not previously been reported. We report a case of Philadelphia positive (Ph+) T cell ALL developing in a patient who previously had FL which may give some insight into the cell of origin and the defects responsible for malignant transformation of the lymphocytes. Bone Marrow Transplantation (2000) 26, 1113–1115.

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  1. Department of Haematology, Birmingham Heartlands Hospital, Birmingham, UK

    RL Auer, J Oates, S Reid, CD Fegan & DW Milligan

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  1. RL Auer
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  2. J Oates
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  3. S Reid
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  4. CD Fegan
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  5. DW Milligan
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Auer, R., Oates, J., Reid, S. et al. Philadelphia-positive T-ALL in a patient with follicular lymphoma. Bone Marrow Transplant 26, 1113–1115 (2000). https://doi.org/10.1038/sj.bmt.1702670

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