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Case Report

Rolandic encephalopathy and epilepsia partialis continua following bone marrow transplant

Abstract

Epilepsia partialis continua (EPC) is a condition defined by prolonged focal myoclonus. Often resistant to therapy, EPC in children is frequently present in Rasmussen encephalitis, a form of chronic encephalitis of uncertain etiology. We discuss a child who developed bilateral EPC 5 months after a bone marrow transplant. Neuroimaging studies showed signal abnormalities on both sensory-motor areas. An extensive search failed to reveal the etiology of the disorder, but treatment with a broad-spectrum anti-viral agent was associated with resolution of the process. An unidentified infectious agent may be responsible for an encephalitis of the motor strip in immunosuppressed patients. Bone Marrow Transplantation (2000) 26, 917–919.

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References

  1. Adams RD, Victor M . Epilepsy and other seizure disorders. In: Adams RD, Victor M (eds) Principles of Neurology McGraw-Hill: New York 1993 p 279

    Google Scholar 

  2. Schomer DL . Focal status epilepticus and epilepsia partialis continua in adults and children Epilepsia 1993 34: (Suppl. 1) S29–S36

    Article  Google Scholar 

  3. Cockerell OC, Rothwell J, Thompson PD et al. Clinical and physiological features of epilepsia partialis continua. Cases ascertained in the UK Brain 1996 119: 393–407

    Article  Google Scholar 

  4. Bartolomei F, Gavaret M, Dhiver C et al. Isolated, chronic epilepsia partialis continua in an HIV-infected patient Arch Neurol 1999 56: 111–114

    Article  CAS  Google Scholar 

  5. Juul-Jensen P, Denny-Brown D . Epilepsia partialis continua. A clinical, electroencephalographic and neuropathological study of nine cases Arch Neurol 1966 15: 563–578

    Article  CAS  Google Scholar 

  6. Kojewnikow AY . Eine besondere form von corticaler epilepsie Neurol Centralbl 1895 14: 47

    Google Scholar 

  7. Omorokow L . Die Kojewnikoffske epilepsie in siberien Z Ges Neurol Psych 1927 107: 487–496

    Article  Google Scholar 

  8. Rogers SW, Andrews PI, Gahring LC et al. Autoantibodies to glutamate receptor GluR3 in Rasmussen’s encephalitis Science 1994 265: 648–51

    Article  CAS  Google Scholar 

  9. Jay V, Becker LE, Otsubo H et al. Chronic encephalitis and epilepsy (Rasmussen’s encephalitis) detection of cytomegalovirus and herpes simplex virus 1 by the polymerase chain reaction and in situ hybridization Neurology 1995 45: 108–117

    Article  CAS  Google Scholar 

  10. Shavit YB, Graus F, Probst A et al. Epilepsia partialis continua: a new manifestation of anti-Hu-associated paraneoplastic encephalomyelitis Ann Neurol 1999 45: 255–258

    Article  CAS  Google Scholar 

Download references

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Antunes, N., Boulad, F., Prasad, V. et al. Rolandic encephalopathy and epilepsia partialis continua following bone marrow transplant. Bone Marrow Transplant 26, 917–919 (2000). https://doi.org/10.1038/sj.bmt.1702637

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