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Case Report

Crohn’s disease complicated by relapsed extranodal Hodgkin’s lymphoma: prolonged complete remission after unmanipulated PBPC autotransplant

Bone Marrow Transplantation volume 26, pages 921–923 (2000)Cite this article

Abstract

Crohn’s disease and ulcerative colitis are inflammatory bowel diseases (IBD), which are thought to result from an inappropriate immunologic (autoimmune) response to luminal antibodies. Allogeneic stem cell transplantation (SCT) performed for coincidental diseases is able to cure both leukaemia and Crohn’s disease. Autologous SCT is currently performed worldwide for severe autoimmune diseases (SADs) because of its reduced transplant-related mortality (TRM). We report the case of a 30-year-old male patient with a 10-year history of severe Crohn’s disease, who developed Hodgkin’s disease and received an unmanipulated peripheral blood autologous transplant. Three years after the transplant the patient is in complete treatment-free remission of both diseases. Bone Marrow Transplantation (2000) 26, 921–923.

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Acknowledgements

We thank Prof Alberto M Marmont for fruitful and stimulating discussions.

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Authors and Affiliations

  1. Unità Operativa di Oncoematologia e Trapianto di Midollo, Ospedale Oncologico ‘La Maddalena’, Palermo, Italy

    F Porretto, A Crescimanno, F Bondì, V Polizzi & R Scalone

  2. Unità Operativa di Oncoematologia e Trapianto di Midollo, Ospedale Oncologico ‘La Maddalena’ Via S Lorenzo Colli 312, 90146 Palermo, Italy

    M Musso

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  1. M Musso
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Musso, M., Porretto, F., Crescimanno, A. et al. Crohn’s disease complicated by relapsed extranodal Hodgkin’s lymphoma: prolonged complete remission after unmanipulated PBPC autotransplant. Bone Marrow Transplant 26, 921–923 (2000). https://doi.org/10.1038/sj.bmt.1702621

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