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Case Report

Post-transplant lymphoproliferative disorder after autologous peripheral stem cell transplantation in a pediatric patient

Bone Marrow Transplantation volume 26, pages 1021–1024 (2000)Cite this article

Abstract

Post-transplant lymphoproliferative disorder (PTLD) is a complication of allogeneic bone marrow transplantation (BMT). Rare cases of PTLD after autologous BMT have been reported only in adults. This case report is the first to describe PTLD in a pediatric patient after autologous peripheral stem cell transplantation (PSCT). This 2-year-old male with stage IV neuroblastoma underwent autologous PSCT. The post-PSCT course was complicated by fever with hematochezia and a lung mass. On day 94 post PSCT, colonoscopy revealed an ulcer due to a PTLD, monomorphic type, B cell phenotype, associated with Epstein–Barr virus. Fine needle aspiration identified the lung mass as neuroblastoma. PTLD can occur in pediatric autologous PSCT recipients, and may occur more frequently in autologous grafts manipulated by T cell depletion or CD34+ cell selection. Bone Marrow Transplantation (2000) 26, 1021–1024.

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Authors and Affiliations

  1. Pathology Department, Children's Hospital of Orange County/St Joseph Hospital, Orange, CA, USA

    MA Lones

  2. Division of Oncology, Children's Hospital of Orange County, Orange, CA, USA

    I Kirov

  3. Department of Pathology and Laboratory Medicine, Center for Health Sciences, University of California Los Angeles, Los Angeles, CA, USA

    JW Said & IP Shintaku

  4. Division of Hematopoietic Stem Cell Transplantation, Children's Hospital of Orange County, Orange, CA, USA

    S Neudorf

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  1. MA Lones
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Lones, M., Kirov, I., Said, J. et al. Post-transplant lymphoproliferative disorder after autologous peripheral stem cell transplantation in a pediatric patient. Bone Marrow Transplant 26, 1021–1024 (2000). https://doi.org/10.1038/sj.bmt.1702593

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