Abstract
Congenital amegakaryocytic thrombocytopenia (CAMT) is an unusual cause of thrombocytopenia without radial or other congenital anomalies in the newborn. Generalized bone marrow dysfunction developing later in life has been reported. We present a 13-month-old girl who was diagnosed as having congenital amegakaryocytic thrombocytopenia and was successfully treated with allogeneic peripheral stem cell transplantation (PSCT) from her fully matched sibling donor. The neutrophil engraftment was on post transplant day 12 and platelet engraftment was on day 14. Her last hemogram revealed platelets of 168 × 109/l 20 months post transplant. Bone Marrow Transplantation (2000) 26, 571–572.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
Purchase on Springer Link
Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Beardsley DS, Nathan DG . Platelet abnormalities in infancy and childhood. In: Nathan DG, Orkin SH (eds) Hematology of Infancy and Childhood WB Saunders: Philadelphia 1998 pp1585–1630
Muraoka K, Ishii E, Tsuji K et al. Defective response to thrombopoietin and impaired expression of c-mpl mRNA of bone marrow cells in congenital amegakaryocytic thrombocytopenia Br J Haematol 1997 96: 287–292
Ihara K, Ishii E, Eguchi M et al. Identification of mutations in the c-mpl gene in congenital amegakaryocytic thrombocytopenia Proc Natl Acad Sci USA 1999 96: 3132–3136
Henter J-I, Winiarski J, Ljungman P et al. Bone marrow transplantation in two children with amegakaryocytic thrombocytopenia Bone Marrow Transplant 1995 15: 799–801
MacMillan ML, Davies SM, Wagner JE, Ramsay NK . Engraftment of unrelated donor stem cells in children with familial amegakaryocytic thrombocytopenia Bone Marrow Transplant 1998 21: 735–737
Bierings M, Bruin M, Revesz T . BMT in two children with congenital amegakaryocytic thrombocytopenia Bone Marrow Transplant 1999 23: (Suppl.1) S173 (Abstr. 573)
Storb R, Champlin RE . Bone marrow transplantation for severe aplastic anemia Bone Marrow Transplant 1991 8: 69–72
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Yeşilipek, M., Hazar, V., Küpesiz, A. et al. Peripheral stem cell transplantation in a child with amegakaryocytic thrombocytopenia. Bone Marrow Transplant 26, 571–572 (2000). https://doi.org/10.1038/sj.bmt.1702558
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bmt.1702558
Keywords
This article is cited by
-
Strategien zur Behandlung von Thrombozytopenien im Kindesalter
Monatsschrift Kinderheilkunde (2006)
-
Allogeneic stem cell transplantation for patients with congenital amegakaryocytic thrombocytopenia (CAT)
Bone Marrow Transplantation (2004)