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Histologic transformation of follicular lymphoma after allogeneic bone marrow transplantation

Bone Marrow Transplantation volume 26, pages 581–583 (2000)Cite this article

Abstract

A 38-year-old man with refractory follicular lymphoma underwent allogeneic BMT from an HLA-identical sibling donor. He had generalized lymphadenopathy, hepatosplenomegaly and lymphoma infiltration of the marrow, all of which disappeared within 3 months following transplantation. Six months post-transplant, progressive hepatomegaly developed in the absence of splenomegaly and lymphadenopathy, and he died from hepatic failure. Autopsy disclosed diffuse large B cell lymphoma of the liver, into which the follicular lymphoma had transformed. Future issues to be investigated should include the optimal timing of allogeneic BMT for low-grade lymphomas. Bone Marrow Transplantation (2000) 26, 581–583.

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Authors and Affiliations

  1. Department of Medicine, Ehime Prefectural Central Hospital, Ehime, Japan

    K Kojima & M Hara

  2. Second Department of Pathology, Okayama University Medical School, Okayama, Japan

    T Mannami & T Yoshino

  3. Department of Surgery, Ehime Prefectural Central Hospital, Ehime, Japan

    H Kawasaki

  4. Department of Pathology, Ehime Prefectural Central Hospital, Ehime, Japan

    K Sasaki, T Maeda & K Furuya

  5. Second Department of Internal Medicine, Okayama University Medical School, Okayama, Japan

    M Harada

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  1. K Kojima
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  2. T Mannami
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  3. T Yoshino
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  4. H Kawasaki
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  7. K Furuya
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  8. M Harada
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  9. M Hara
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Kojima, K., Mannami, T., Yoshino, T. et al. Histologic transformation of follicular lymphoma after allogeneic bone marrow transplantation. Bone Marrow Transplant 26, 581–583 (2000). https://doi.org/10.1038/sj.bmt.1702547

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  • DOI: https://doi.org/10.1038/sj.bmt.1702547

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