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Viral Infections

CMV pneumonia in allogeneic BMT recipients undergoing early treatment or pre-emptive ganciclovir therapy

Bone Marrow Transplantation volume 26, pages 413–417 (2000)Cite this article

Abstract

The incidence, treatment and outcome of CMV interstitial pneumonia (CMV-IP) were reviewed in 139 consecutive allogeneic BMT patients undergoing extended CMV antigenemia surveillance and two different ganciclovir (GCV) strategies to control CMV infection. Nineteen cases of CMV-IP were reviewed, 16 of 63 patients (25.4%) who received early GCV treatment (ET) and three of 76 patients (3.9%) who received pre-emptive (PE) GCV therapy. In the ET group, the median time for occurrence of CMV-IP was 55 (range 36 to 311) days. Two patients had three episodes of CMV-IP recurrences after day +100. CMV-IP-related death occurred in two patients (15.4%). In the PE group, 41 patients received pre-emptive GCV therapy prompted by the appearance of positive antigenemia ⩾2 cells. The median time for the occurrence of CMV-IP was 92 (range 48 to 197) days. Response to therapy was observed when GCV was introduced within 6 days of antigenemia positivity. The use of IVIg in association with GCV did not play a major role in response to therapy. The median time for occurrence of CMV-IP was delayed during PE strategy and the cost-effectiveness of CMV surveillance after day +100 should be investigated in this population. Bone Marrow Transplantation (2000) 26, 413–417.

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Authors and Affiliations

  1. BMT Program, Fundação Pró Sangue Hemocentro de São Paulo, Discipline of Hematology, São Paulo, Brazil

    CM Machado, FL Dulley, MCA Macedo, RL Silva, R Pallota & RS Saboya

  2. Virology Laboratory of Instituto de Medicina Tropical de São Paulo, São Paulo, Brazil

    CM Machado, LSVilas Boas & CS Pannuti

  3. Pathology Department of INCOR-HC, University of São Paulo Medical School, São Paulo, Brazil

    JB Castelli

Authors
  1. CM Machado
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  2. FL Dulley
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Machado, C., Dulley, F., Boas, L. et al. CMV pneumonia in allogeneic BMT recipients undergoing early treatment or pre-emptive ganciclovir therapy. Bone Marrow Transplant 26, 413–417 (2000). https://doi.org/10.1038/sj.bmt.1702526

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  • DOI: https://doi.org/10.1038/sj.bmt.1702526

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